Bibliographic Details
| Title: |
Synergistic effect of follicle-stimulating hormone receptor and androgen receptor gene variants on semen quality. |
| Authors: |
Lazaros, L.1, Xita, N.2, Takenaka, A.3, Sofikitis, N.4, Makrydimas, G.1, Stefos, T.1, Kosmas, I.5, Zikopoulos, K.1, Hatzi, E.1, Georgiou, I.1 |
| Superior Title: |
Andrologia. Oct2013, Vol. 45 Issue 5, p339-344. 6p. 2 Charts, 2 Graphs. |
| Subject Terms: |
*FOLLICLE-stimulating hormone receptor, *ANDROGEN receptors, *SEMEN analysis, *SPERMATOZOA, *GENETIC polymorphisms, *COLLEGE teachers |
| Abstract: |
Follicle-stimulating hormone ( FSH), interacting with its receptor ( FSHR), participates in the production of spermatozoa and androgens. Androgens exert their effects on male sex determination, development and sperm production by binding to androgen receptor ( AR). In the present study, we sought to explore the potential synergistic effects of FSHR and AR gene variants on sperm quality. 200 oligozoospermic and 250 normozoospermic men were examined. DNA was extracted from spermatozoa, and the FSHR 307 ( T/A), FSHR 680 ( N/S) and AR ( CAG) n polymorphisms were genotyped. Their parallel analysis revealed six combined genotypes. A gradual reduction of sperm motility, from long AR allele- Thr307 Thr/Asn680Asn carriers to long AR allele- Ala307 Ala/ Ser680 Ser carriers and from short AR allele- Thr307 Thr/ Asn680 Asn carriers to short AR allele- Ala307 Ala/ Ser680 Ser carriers was revealed in normozoospermic men ( P < 0.001). Similar associations were observed in oligozoospermic men ( P < 0.001). In our series, the synergism of the long AR alleles with the FSHRThr307/ Asn680 allelic variant was associated with increased sperm motility, while the synergism of the short AR alleles with the FSHRAla307/ Ser680 allelic variant was associated with decreased motility, supporting the significance of these genes in semen quality. [ABSTRACT FROM AUTHOR] |
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