Bibliographic Details
| Title: |
Effects of game-based digital therapeutics on attention deficit hyperactivity disorder in children and adolescents as assessed by parents or teachers: a systematic review and meta-analysis. |
| Authors: |
Oh, SuA1, Choi, Jina2, Han, Doug Hyun3, Kim, EunYoung1,2,4 eykimjcb777@cau.ac.kr |
| Superior Title: |
European Child & Adolescent Psychiatry. Feb2024, Vol. 33 Issue 2, p481-493. 13p. |
| Subject Terms: |
*TREATMENT of attention-deficit hyperactivity disorder, *ONLINE information services, *PSYCHOLOGY information storage & retrieval systems, *PSYCHOLOGY of parents, *META-analysis, *MEDICAL information storage & retrieval systems, *CONFIDENCE intervals, *SYSTEMATIC reviews, *IMPULSIVE personality, *PSYCHOLOGY of teachers, *DIGITAL health, *HEALTH outcome assessment, *CHILD behavior, *TEENAGERS' conduct of life, *DESCRIPTIVE statistics, *RESEARCH funding, *VIDEO games, *MEDLINE, *NEW product development laws, *MEDICAL equipment, *CHILDREN, *ADOLESCENCE |
| Company/Entity: |
UNITED States. Food & Drug Administration |
| Abstract: |
Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by pharmacological and non-pharmacological interventions. Despite the available treatment options and prevention measures, conventional treatments have several limitations. Digital therapeutics (DTx) like EndeavorRx® is an emerging alternative to overcome these limitations. EndeavorRx® is the first FDA-approved, game-based DTx approved for the treatment of pediatric ADHD. We investigated the effects of game-based DTx in randomised controlled trials (RCTs) on children and adolescents with ADHD. In this systematic review and meta-analysis, we searched PubMed, Embase, and PsycINFO databases up to January 2022. The protocol was registered (CRD42022299866). The assessor was defined as parents and teachers. The primary outcome was differences in inattention reported by the assessor, and the secondary outcome was differences in hyperactivity and hyperactivity/impulsivity reported by the assessor and the relative comparisons between game-based DTx, medicine, and control with indirect meta-analysis. Game-based DTx improved inattention more than the control upon assessment by assessors (standard mean difference (SMD) 0.28, 95% confidence interval (CI) 0.14–0.41; SMD 0.21, 95% CI 0.03–0.39, respectively), while medication improved inattention more than game-based DTx (SMD − 0·62, 95% CI − 1·04 to − 0·20) upon assessment by the teacher. Game-based DTx improved hyperactivity/impulsivity than the control upon assessment by assessors (SMD 0.28, 95% CI 0.03–0.53; SMD 0.30, 95% CI 0.05–0.55, respectively), and medication improved hyperactivity/impulsivity significantly than game-based DTx upon assessment by the teacher. Hyperactivity has not been reported extensively. As a result, game-based DTx had a more significant effect than the control, however medication was more effective. [ABSTRACT FROM AUTHOR] |
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| Database: |
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