Academic Journal
Preclinical modeling of lower-grade gliomas
| Title: | Preclinical modeling of lower-grade gliomas |
|---|---|
| Authors: | Tang, Lilly W., Mallela, Arka N., Deng, Hansen, Richardson, Timothy E., Hervey-Jumper, Shawn L., McBrayer, Samuel K., Abdullah, Kalil G. |
| Superior Title: | Front Oncol |
| Publisher Information: | Frontiers Media S.A. |
| Publication Year: | 2023 |
| Collection: | PubMed Central (PMC) |
| Subject Terms: | Oncology |
| Description: | Models for human gliomas prove critical not only to advancing our understanding of glioma biology but also to facilitate the development of therapeutic modalities. Specifically, creating lower-grade glioma (LGG) models has been challenging, contributing to few investigations and the minimal progress in standard treatment over the past decade. In order to reliably predict and validate the efficacies of novel treatments, however, LGG models need to adhere to specific standards that recapitulate tumor genetic aberrations and micro-environment. This underscores the need to revisit existing models of LGG and explore prospective models that may bridge the gap between preclinical insights and clinical translation. This review first outlines a set of criteria aimed to address the current challenges hindering model development. We then evaluate the strengths and weaknesses of existing preclinical models of LGG with respect to these established standards. To conclude, the review discusses potential future directions for integrating existing models to maximize the exploration of disease mechanisms and therapeutics development. |
| Document Type: | text |
| Language: | English |
| Relation: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083350/; http://www.ncbi.nlm.nih.gov/pubmed/37051530; http://dx.doi.org/10.3389/fonc.2023.1139383 |
| DOI: | 10.3389/fonc.2023.1139383 |
| Availability: | https://doi.org/10.3389/fonc.2023.1139383 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083350/ http://www.ncbi.nlm.nih.gov/pubmed/37051530 |
| Rights: | Copyright © 2023 Tang, Mallela, Deng, Richardson, Hervey-Jumper, McBrayer and Abdullah ; https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Accession Number: | edsbas.DBE96E72 |
| Database: | BASE |
| Description not available. |