Dissertation/ Thesis
DOPRINOS GAMMA DELTA (ɣδ) T-LIMFOCITA U RAZVOJU TIPA 2 UPALE U SINONAZALNOJ SLUZNICI OBOLJELIH OD KRONIČNOG ALERGIJSKOG RINOSINUITISA S NOSNOM POLIPOZOM
| Title: | DOPRINOS GAMMA DELTA (ɣδ) T-LIMFOCITA U RAZVOJU TIPA 2 UPALE U SINONAZALNOJ SLUZNICI OBOLJELIH OD KRONIČNOG ALERGIJSKOG RINOSINUITISA S NOSNOM POLIPOZOM |
|---|---|
| Authors: | Milanković, Stjepan Grga |
| Contributors: | Mihalj, Hrvoje, Tokić, Stana |
| Publisher Information: | Sveučilište Josipa Jurja Strossmayera u Osijeku. Doktorska škola. Josip Juraj Strossmayer University of Osijek. Doctoral studies. |
| Publication Year: | 2024 |
| Collection: | Repository of the University of Osijek |
| Subject Terms: | BIOTEHNIČKE ZNANOSTI. Biotehnologija. Molekularna biotehnologija, BIOTECHNICAL SCIENCES. Biotechnology. Molecular Biotechnology, Medicina, Medical sciences, info:eu-repo/classification/udc/61(043.3), kronični rinosinuitis, nosna polipoza, gamma delta T-limfociti, Th2 upala, chronic rhinosinusitis, nasal polyps, gamma delta T-lymphocytes, Th2 inflammation |
| Description: | Metodom protočne citometrije zabilježena je povećana distribucija subpopulacija δ1-δ2- γδ T-limfocita u sinonazalnoj sluznici bolesnika s eKRSsNP. Također, metodom RT-qPCR zabilježen je povećan genski izražaj CCR3 i IL-13 u sinonazalnoj sluznici bolesnika s eKRSsNP u odnosu na sinonazalnu sluznicu kontrolnih ispitanika. U ovom istraživanju dokazana je važna uloga γδ T-limfocita u nastanku eKRSsNP, kao i snažna veza između opisanih stanica i IL-13 – važnog citokina upale tipa 2. ; An increased distribution of δ1-δ2- subpopulations γδ T-lymphocytes in the sinonasal mucosa of patients with eosinophilic chronic rhinosinusitis with nasal polyposis (eCRSwNP) was detected using the flow cytometry method. Also, using the RT-qPCR method, increased gene expression of CCR3 and IL-13 was recorded in the sinonasal mucosa of eCRSwNP patients compared to sinonasal mucosa of controls. In this research, we proved the importance of γδ T-lymphocytes in the development of eCRSwNP, as well as the strong connection between the described cells and the IL-13 – important cytokine of type 2 inflammation. |
| Document Type: | doctoral or postdoctoral thesis |
| File Description: | application/pdf |
| Language: | Croatian |
| Relation: | https://repozitorij.unios.hr/islandora/object/dsos:127; https://urn.nsk.hr/urn:nbn:hr:236:531891; https://repozitorij.unios.hr/islandora/object/dsos:127/datastream/PDF |
| Availability: | https://repozitorij.unios.hr/islandora/object/dsos:127 https://urn.nsk.hr/urn:nbn:hr:236:531891 https://repozitorij.unios.hr/islandora/object/dsos:127/datastream/PDF |
| Rights: | http://rightsstatements.org/vocab/InC/1.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.936CB960 |
| Database: | BASE |
| Description not available. |