Bibliographic Details
| Title: |
Concurrent Adjacent Merkel Cell Carcinoma and Chronic Lymphocytic Leukemia without Simultaneous Merkel Cell Polyomavirus Detection: A Case Series |
| Authors: |
Rayan Saade, Saleh Najjar, Mustafa Erdem Arslan, Peter Rady, Stephen K. Tyring, Tipu Nazeer |
| Superior Title: |
Dermatopathology; Volume 8; Issue 2; Pages: 190-201 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2021 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
Merkel cell carcinoma, CLL/SLL, Merkel cell polyomavirus, concurrent tumorigenesis |
| Description: |
Background: The association between Merkel cell carcinoma (MCC) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL) is well established in the literature. A majority of MCCs are known to be associated with Merkel cell carcinoma polyomavirus (MCPyV), which is postulated to be a possible causative agent linking these two entities. We aim to identify the presence of MCPyV in patients with concurrent adjacent MCC and CLL/SLL. Methods: Archived pathology materials of three cutaneous or surgical excisions with concurrent MCC and CLL/SLL were reviewed. Additional 12-µm sections from paraffin-embedded tissue of these resections were matched with original hematoxylin and eosin-stained slides and used to extract foci from each tumor separately. DNA was extracted from these tissues, and polymerase chain reaction (PCR), utilizing a primer set within a highly conserved “small T” viral DNA region, was done to detect MCPyV. Results: Out of 140 cases of cutaneous or surgical excisions with MCC identified in our electronic medical records (EMR), three had coexisting neighboring CLL/SLL in the same resection specimen. In one case out of three, MCPyV was detected in MCC but not in CLL/SLL. The remaining two cases showed no detection of MCPyV in either MCC or CLL/SLL. Conclusion: MCPyV was not concurrently associated with adjacent MCC and CLL/SLL, indicating that it is not driving simultaneous tumorigenesis, at least in a subset of these cases. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Molecular Dermatopathology; https://dx.doi.org/10.3390/dermatopathology8020025 |
| DOI: |
10.3390/dermatopathology8020025 |
| Availability: |
https://doi.org/10.3390/dermatopathology8020025 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.152D4592 |
| Database: |
BASE |
