Bibliographic Details
| Title: |
Effects of Vardenafil on Testicular Torsion/Detorsion Damage: An Experimental Study in Pigs. |
| Authors: |
Istanbulluoglu, Mustafa Okan, Zor, Murat, Celik, Asuman, Cicek, Tufan, Basal, Seref, Ozgok, Aysegul, Ustun, Huseyin, Ozgok, Yasar |
| Superior Title: |
Urologia Internationalis; Mar2011, Vol. 86 Issue 2, p228-232, 5p, 2 Color Photographs, 2 Charts |
| Subject Terms: |
SPERMATIC cord torsion, PHOSPHODIESTERASE inhibitors, LABORATORY swine, GERM cells, APOPTOSIS, NITRIC oxide, OXIDATIVE stress, HISTOPATHOLOGY |
| Abstract: |
Purpose: To investigate the effects of vardenafil HCl on testicular germ cell apoptosis and the expressions of iNOS and eNOS within the bilateral testes after unilateral torsion/detorsion (T/D) in a pig model. Methods: 12 male pigs weighing 50-55 kg were divided randomly into three groups (n = 4). Sham operation and T/D was performed in groups 1 and 2, respectively. Group 3 underwent T/D and received vardenafil (0.4 mg/kg) orally 45 min before detorsion. The testes were left in torsion for 2 h. In all groups, both testes were removed 8 h after the operation for histopathological analysis. Results: Except for group 1, the histopathologic parameters of the ipsilateral testes were higher than in the contralateral testes, and this difference was statistically significant (p < 0.05). Testicular ischemia/reperfusion (I/R) (group 2) resulted in marked increases in germ cell apoptosis, iNOS and eNOS in the ischemic testes compared to the sham-operated group. The pigs treated with vardenafil (group 3) also showed significantly increased apoptotic cells, iNOS and eNOS levels compared to the sham-operated group. Conclusions: The results suggest that vardenafil HCl worsened histopathological changes related to oxidative stress in testicular injury and had no protective effect on testicular I/R injury in pigs. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
