Bibliographic Details
| Title: |
Structural Characterization of Canine Minute Virus, Rat and Porcine Bocavirus. |
| Authors: |
Velez, Michael, Mietzsch, Mario, Hsi, Jane, Bell, Logan, Chipman, Paul, Fu, Xiaofeng, McKenna, Robert |
| Superior Title: |
Viruses (1999-4915); Sep2023, Vol. 15 Issue 9, p1799, 13p |
| Subject Terms: |
MISCARRIAGE, CAPSIDS, PARVOVIRUSES, RATS, VIRAL vaccines, ENCEPHALOMYELITIS, PIGLETS, DOGS |
| Abstract: |
Bocaparvovirus is an expansive genus of the Parvovirinae, with a wide range of vertebrate hosts. This study investigates Canine minute virus (CnMV), Rat bocavirus (RBoV), and Porcine bocavirus 1 (PBoV1). Both CnMV and PBoV1 have been found in gastrointestinal infections in their respective hosts, with CnMV responsible for spontaneous abortions in dogs, while PBoV has been associated with encephalomyelitis in piglets. The pathogenicity of the recently identified RBoV is currently unknown. To initiate the characterization of these viruses, their capsids structures were determined by cryo-electron microscopy at resolutions ranging from 2.3 to 2.7 Å. Compared to other parvoviruses, the CnMV, PBoV1, and RBoV capsids showed conserved features, such as the channel at the fivefold symmetry axis. However, major differences were observed at the two- and threefold axes. While CnMV displays prominent threefold protrusions, the same region is more recessed in PBoV1 and RBoV. Furthermore, the typical twofold axis depression of parvoviral capsids is absent in CnMV or very small in PBoV and RBoV. These capsid structures extend the structural portfolio for the Bocaparvovirus genus and will allow future characterization of these pathogens on a molecular level. This is important, as no antivirals or vaccines exist for these viruses. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
