Bibliographic Details
| Title: |
降压药物相关基因多态性在某院高血压患者中的应用研究. (Chinese) |
| Alternate Title: |
Antihypertensive drug-related genes polymorphisms in hypertensive patients at a certain hospital. (English) |
| Authors: |
张露潆, 付士辉, 陈羽翔, 甯超学, 杨婷, 陈玉剑, 朱乔, 赵亚力 |
| Superior Title: |
China Tropical Medicine; Nov2022, Vol. 22 Issue 11, p1066-1072, 7p |
| Abstract (English): |
Objective By analyzing the frequency distribution of antihypertensive drug-related genotypes in hypertensionpatients treated in our hospital, so as to provide a clinical basis for individualized treatment of hypertension patients. Methods A total of 72 hypertensive patients treated in Hainan Hospital of PLA General Hospital from June 2021 to April 2022 were collected. PCR-melting curve method was used to detect CYP2D6*10 (c.100 C>T), CYP2C9*3 (c.1075 A>C), ADRB1 (c.1165 G>C), AGTR1 (c.1166 A>C), ACE (I/D), NPPA (T2238C) and CYP3A5*3 (A6986G), and the relationship between different genotypes and biochemical indexes was analyzed. Results According to the statistics of the gene and genotype frequency of each point in 72 patients, the gene frequencies of 7 sites all conformed to Hardy Weinberg equilibrium. There were gender differences in ADRB1 genotypes (χ2 = 5.878, P<0.05). There were statistical differences in triglycerides [AA: 1.4 (1.0, 2.0)mmol/L; AC: 2.2 (1.5, 2.5)mmol/L; P=0.038], total cholesterol [AA: 4.0 (3.1, 4.9) mmol/L; AC: 4.8 (4.0, 5.3) mmol/L; P=0.040] and low-density lipoprotein cholesterol [(AA: 2.4 (1.8, 3.3) mmol/L; AC: 3.2 (2.5, 3.5) mmol/L; P=0.035] among patients with different genotypes of AGTR1 locus. The patients with different genotypes of CYP2C9 locus had significant differences in their alanine transferase (ALT) [AA:16.9 (11.4,30.2) mmol/L; AC:10.4 (9.4, 18.2) mmol/L; P=0.040]. Aftergene-directed individualized therapy, different genotypes of CYP3A5 andAGTR1 affected the heart rate [CYP3A5: AA: (79.3±7.0) beats/min; AG: (69.8±6.8) beats/min; GG: (68.8±7.3) beats/min; P=0.010], systolic blood pressure [AGTR1: AA: (131.3± 16.7) mmHg; AC: (140.6±11.8) mmHg; P=0.014] and diastolic blood pressure [CYP3A5: AA: (90.0±8.3) mmHg; AG: (78.7± 10.8) mmHg; GG: (74.9± 10.7) mmHg; P=0.025; AGTR1: AA: (75.3± 10.2) mmHg; AC: (86.3± 10.6) mmHg; P=0.001] of patients. Conclusions The related gene loci of antihypertensive drugs are an important basis for guiding the diversification and individualization of clinical medication. Clinicians need to consider the impact of related genes on drug efficacy and adverse reactions when prescribing. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的分析来我院就诊高血压患者中降压药物相关基因型的频率分布, 为高血压患者个体化治疗提供参 考和临床依据。方法收集2021年6月--2022年4月在中国人民解放军总医院海南医院就诊的高血压患者, 共72例。 采用PCR-熔解曲线法检测CYP2D6*10（c.100 C>T）、CYP2C9*3（c.1075 A>C）、ADRB1（c.1165 G>C）、AGTR1（c.1166 A> C）、ACE（I/D）、NPPA（T2238C）和CYP3A5*3（A6986G）, 并分析不同基因型与生化指标的关系。结果对72例患者各 位点基因及基因型频率进行统计, 7个位点基因频率均符合Hardy-Weinberg平衡。ADRB1基因型存在性别差异（χ2= 5.878, P<0.05）。AGTR1 位点不同基因型的患者之间三酰甘油[AA:1.4（1.0, 2.0）mmol/L;AC：2.2（1.5, 2.5）mmol/L; P=0.038]、总胆固醇[AA:4.0（3.1, 4.9）mmol/L;AC：4.8（4.0, 5.3）mmol/L;P=0.040]、低密度脂蛋白胆固醇[AA:2.4（1.8, 3.3）mmol/L;AC：3.2（2.5, 3.5）mmol/L;P=0.035]水平存在统计学差异。CYP2C9位点不同基因型的患者之间谷丙转移 酶水平[AA:16.9（11.4, 30.2）mmol/L;AC：10.4（9.4, 18.2）mmol/L;P=0.040]存在统计学差异。个体化治疗干预后, CYP3A5、AGTR1位点不同基因型影响患者的心率[CYP3A5: AA（: 79.3±7.0）次/min;AG：（69.8±6.8）次/min;GG：（68.8± 7.3）次/min;P=0.010）]、收缩压[AGTR1: AA:（131.3±16.7）mmHg;AC：（140.6±11.8）mmHg;P=0.014]和舒张压[CYP3A5: AA:（90.0±8.3）mmHg;AG：（78.7±10.8）mmHg;GG：（74.9±10.7）mmHg;P=0.025; AGTR1: AA:（75.3±10.2）mmHg;AC： （86.3±10.6）mmHg;P=0.001]。结论降压药物的相关基因位点是指导临床用药多样化、个体化的重要依据, 临床医生 在开具处方时需要考虑相关基因对药物疗效和不良反应的影响. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
