Bibliographic Details
| Title: |
Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis. |
| Authors: |
Das, Rajsekhar1, Sinha, Sumit2, Xin Li1, Kirkpatrick, T. R.3, Thirumalai, D.1,2 dave.thirumalai@gmail.com |
| Superior Title: |
eLife. 1/19/2024, p1-30. 30p. |
| Subject Terms: |
*VISCOSITY, *FETAL tissues, *BLASTODERM, *CELL size, *TISSUES, *RHEOLOGY (Biology) |
| Abstract: |
A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity (η) of a non-confluent embryonic tissue grows sharply until a critical cell packing fraction (ϕS). The increase in η up to ϕS is similar to the behavior observed in several glass-forming materials, which suggests that the cell dynamics is sluggish or glass-like. Surprisingly, η is a constant above ϕS. To determine the mechanism of this unusual dependence of η on ϕ, we performed extensive simulations using an agent-based model of a dense non-confluent two-dimensional tissue. We show that polydispersity in the cell size, and the propensity of the cells to deform, results in the saturation of the available free area per cell beyond a critical packing fraction. Saturation in the free space not only explains the viscosity plateau above ϕS but also provides a relationship between equilibrium geometrical packing to the dramatic increase in the relaxation dynamics. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Premier |
