Bibliographic Details
| Title: |
EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF FLEMINGIA STROBILIFERA R. BR IN ZINC DISC-INDUCED UROLITHIASIS: AN ANIMAL MODEL STUDY. |
| Authors: |
Kumara, Anil1 anilkims98@gmail.com, Anil Kumar K. V.1, Swaroopa Rani N. C.2, Aditya V.3, Girish B. S.3 |
| Superior Title: |
Indian Drugs. Dec2023, Vol. 60 Issue 12, p75-81. 7p. |
| Subject Terms: |
*URINARY calculi, *KIDNEY stones, *ZINC, *ANIMAL models in research, *GASTRIC intubation, *PLANT extracts, *RATS |
| Abstract: |
Kidney stones are painful and do not have complete successful therapy. Therefore, the objective of this work was to assess the antiurolithiatic activity of Flemingia strobilifera R. Br in zinc-induced nephrolithiasis. Preliminary phytochemical analysis of plant leaf extracts in chloroform was carried out. To induce urolithiasis in male Wistar rats, zinc discs were implanted surgically. Then, following the protocol, plant leaf chloroform extract (60 mg kg-1) was administered via gastric intubation, and post-experimental evaluations were performed to ascertain the impact of the plant extract. In zinc disc-induced urolithiasis, the plant F. strobilifera leaves chloroform extract elicits exhibited statistically noteworthy reduction in occurrence of urinary stones and facilitated the dissolution of existing stones by lowering their size. The F. strobilifera plant's leaf chloroform extract has been discovered to have significant antiurolithiatic action in terms of reducing and preventing the emergence of renal calculi. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Premier |