Bibliographic Details
| Title: |
A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut. |
| Authors: |
Oikonomou, Panagiotis1, Cirne, Helena C.1, Nerurkar, Nandan L.1 nln2113@columbia.edu |
| Superior Title: |
Development (09501991). Nov2023, Vol. 150 Issue 22, p1-12. 12p. |
| Subject Terms: |
*MESODERM, *ENDODERM, *FIBROBLAST growth factors, *TISSUE mechanics, *CELL motility, *GASTRULATION, *PROTEOLYSIS |
| Abstract: |
Although mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics remains understudied during vertebrate morphogenesis. Here, we developed a two-dimensional chemo-mechanical model to investigate how mechanical properties of the endoderm and transport properties of fibroblast growth factor (FGF) regulate avian hindgut morphogenesis in a coordinated manner. Posterior endoderm cells convert a gradient of FGF ligands into a contractile force gradient, leading to a force imbalance that drives collective cell movements that elongate the forming hindgut tube. We formulated a 2D reaction-diffusionadvection model describing the formation of an FGF protein gradient as a result of posterior displacement of cells transcribing unstable Fgf8 mRNA during axis elongation, coupled with translation, diffusion and degradation of FGF protein. The endoderm was modeled as an active viscous fluid that generates contractile stresses in proportion to FGF concentration. With parameter values constrained by experimental data, the model replicates key aspects of hindgut morphogenesis, suggests that graded isotropic contraction is sufficient to generate large anisotropic cell movements, and provides new insight into how chemo-mechanical coupling across the mesoderm and endoderm coordinates hindgut elongation with axis elongation. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Premier |
