Bibliographic Details
| Title: |
TALE transcription factors: Cofactors no more. |
| Authors: |
Bobola, Nicoletta1 (AUTHOR) Nicoletta.Bobola@manchester.ac.uk, Sagerström, Charles G.1,2 (AUTHOR) Charles.sagerstrom@cuanschutz.edu |
| Superior Title: |
Seminars in Cell & Developmental Biology. Jan2024, Vol. 152, p76-84. 9p. |
| Subject Terms: |
*TRANSCRIPTION factors, *FETAL tissues, *MORPHOGENESIS, *BINDING sites, *CONGENITAL disorders |
| Abstract: |
Exd/PBX, Hth/MEIS and PREP proteins belong to the TALE (three-amino-acid loop extension) superclass of transcription factors (TFs) with an atypical homedomain (HD). Originally discovered as "cofactors" to HOX proteins, revisiting their traditional role in light of genome-wide experiments reveals a strong and reproducible pattern of HOX and TALE co-occupancy across diverse embryonic tissues. While confirming that TALE increases HOX specificity and selectivity in vivo, this wider outlook also reveals novel aspects of HOX:TALE collaboration, namely that HOX TFs generally require pre-bound TALE factors to access their functional binding sites in vivo. In contrast to the restricted expression domains of HOX TFs, TALE factors are largely ubiquitous, and PBX and PREP are expressed at the earliest developmental stages. PBX and MEIS control development of many organs and tissues and their dysregulation is associated with congenital disease and cancer. Accordingly, many instances of TALE cooperation with non HOX TFs have been documented in various systems. The model that emerges from these studies is that TALE TFs create a permissive chromatin platform that is selected by tissue-restricted TFs for binding. In turn, HOX and other tissue-restricted TFs selectively convert a ubiquitous pool of low affinity TALE binding events into high confidence, tissue-restricted binding events associated with transcriptional activation. As a result, TALE:TF complexes are associated with active chromatin and domain/lineage-specific gene activity. TALE ubiquitous expression and broad genomic occupancy, as well as the increasing examples of TALE tissue-specific partners, reveal a universal and obligatory role for TALE in the control of tissue and lineage-specific transcriptional programs, beyond their initial discovery as HOX co-factors. • TALE TFs were originally discovered as "cofactors" for HOX proteins. • TALE proteins are largely ubiquitous and also expressed in HOX-less domains. • TALE TFs cooperate extensively with non-HOX TFs in vivo. • TALE TFs are broadly required to initiate tissue-restricted transcriptional programs. • In light of recent work, "HOX cofactor" is too restrictive in describing TALE function. [ABSTRACT FROM AUTHOR] |
|
Copyright of Seminars in Cell & Developmental Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Premier |
