Search Results - PHOSPHODIESTERASE inhibitors

1

Academic Journal

Phosphodiesterase inhibitor ameliorates senescent changes of renal interstitial pericytes in aging kidney.

Authors: Kim, Hyung Duk¹ (AUTHOR), Kim, Eun Nim² (AUTHOR), Lim, Ji Hee² (AUTHOR), Kim, Yaeni³ (AUTHOR), Ban, Tae Hyun¹ (AUTHOR), Lee, Hajeong⁴ (AUTHOR), Kim, Yon Su⁴ (AUTHOR), Park, Cheol Whee³ (AUTHOR), Choi, Bum Soon¹ (AUTHOR) sooncb@catholic.ac.kr

Superior Title: Aging Cell. Mar2024, Vol. 23 Issue 3, p1-14. 14p.

Subject Terms: *PERICYTES, *PHOSPHODIESTERASE inhibitors, *AGING, *CELLULAR aging, *KIDNEYS, *RENAL fibrosis, *DEAD

HTML Full Text PDF Full Text

2

Academic Journal

Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.

Authors: Silva, Alex Luiz Menezes da¹ (AUTHOR) aalexmenezess@gmail.com, Nascimento, Chirlene Pinheiro¹ (AUTHOR), Azevedo, Julianne Elba Cunha¹ (AUTHOR), Vieira, Luana Rodrigues¹ (AUTHOR), Hamoy, Akira Otake¹ (AUTHOR), Tiago, Allan Carlos da Silva¹ (AUTHOR), Martins Rodrigues, João Cleiton² (AUTHOR), de Araujo, Daniella Bastos¹ (AUTHOR), Favacho Lopes, Dielly Catrina² (AUTHOR), de Mello, Vanessa Jóia¹ (AUTHOR), Hamoy, Moisés¹ (AUTHOR)

Superior Title: PLoS ONE. 11/30/2023, Vol. 18 Issue 11, p1-18. 18p.

Subject Terms: *PHENOBARBITAL, *PHOSPHODIESTERASE inhibitors, *PHOSPHODIESTERASE-5 inhibitors, *SILDENAFIL, *DURA mater, *CENTRAL nervous system, *FREQUENCIES of oscillating systems

HTML Full Text PDF Full Text

3

Academic Journal

Predictors of the response to phosphodiesterase-5 inhibitors in pulmonary arterial hypertension: an analysis of the Spanish registry.

Authors: Garcia, Agustin R.^1,2 (AUTHOR), Blanco, Isabel^1,2 (AUTHOR), Ramon, Lluis^1,2 (AUTHOR), Pérez-Sagredo, Jesús³ (AUTHOR), Guerra-Ramos, Francisco J.⁴ (AUTHOR), Martín-Ontiyuelo, Clara^1,2 (AUTHOR), Tura-Ceide, Olga^1,2 (AUTHOR), Pastor-Pérez, Francisco⁵ (AUTHOR), Escribano-Subías, Pilar^6,7 (AUTHOR), Barberà, Joan A.^1,2 (AUTHOR) jbarbera@clinic.cat

Superior Title: Respiratory Research. 9/15/2023, Vol. 24 Issue 1, p1-11. 11p.

Subject Terms: *PULMONARY arterial hypertension, *PHOSPHODIESTERASE inhibitors, *PHOSPHODIESTERASE-5 inhibitors, *DISEASE risk factors, *ENDOTHELIN receptors, *ANTINUCLEAR factors

HTML Full Text PDF Full Text

4

Academic Journal

Differential effects of two phosphodiesterase 4 inhibitors against lipopolysaccharide-induced neuroinflammation in mice.

Authors: Kang, Dong Ho^1,2 (AUTHOR), Ahn, Sunjoo¹ (AUTHOR), Chae, Jung Woo² (AUTHOR), Song, Jin Sook¹ (AUTHOR) jssong@krict.re.kr

Superior Title: BMC Neuroscience. 7/31/2023, Vol. 24 Issue 1, p1-11. 11p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *ORAL drug administration, *NEUROINFLAMMATION, *CENTRAL nervous system, *MICE, *P-glycoprotein

HTML Full Text PDF Full Text

5

Academic Journal

Phosphodiesterase inhibitors in psychiatric disorders.

Authors: Sadeghi, Mohammad Amin^1,2 (AUTHOR), Nassireslami, Ehsan^1,2 (AUTHOR), Yousefi Zoshk, Mojtaba^3,4 (AUTHOR), Hosseini, Yasaman⁵ (AUTHOR), Abbasian, Kourosh⁶ (AUTHOR), Chamanara, Mohsen^1,2 (AUTHOR) chamanaramohsen@gmail.com

Superior Title: Psychopharmacology. Jun2023, Vol. 240 Issue 6, p1201-1219. 19p. 5 Charts.

Subject Terms: *MENTAL illness, *PHOSPHODIESTERASE inhibitors, *BIPOLAR disorder, *POST-traumatic stress disorder, *MENTAL depression, *ENZYME inhibitors, *SILDENAFIL

HTML Full Text PDF Full Text

6

Academic Journal

Renal and cardiac effects of the PDE9 inhibitor BAY 73–6691 in 5/6 nephrectomized rats.

Authors: Chen, Xin^1,2,3 (AUTHOR), Delić, Denis^1,4 (AUTHOR), Cao, Yaochen^1,2 (AUTHOR), Zhang, Zeyu³ (AUTHOR), Wu, Hongwei³ (AUTHOR), Hasan, Ahmed A.¹ (AUTHOR), Gaballa, Mohamed M. S.⁵ (AUTHOR), Yin, Lianghong³ (AUTHOR), Krämer, Bernhard K.^1,6 (AUTHOR), Klein, Thomas⁷ (AUTHOR), Shi, Xin⁸ (AUTHOR), He, Ben⁸ (AUTHOR), Shen, Linghong⁸ (AUTHOR), Hocher, Berthold^1,9,10 (AUTHOR) berthold.hocher@medma.uni-heidelberg.de

Superior Title: Pflügers Archiv: European Journal of Physiology. May2024, Vol. 476 Issue 5, p755-767. 13p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *PROTEIN kinase B, *RENAL fibrosis, *NF-kappa B, *RATS, *PHOSPHATIDYLINOSITOL 3-kinases

Zugang prüfen (DOI)

7

Academic Journal

Phosphodiesterase type 5 inhibitors related hearing impairment: a real world study based on the FDA adverse event reporting system.

Authors: Zhang, Xunyan¹ (AUTHOR), Xia, Lu² (AUTHOR), Yang, Qiang¹ (AUTHOR), Tang, Pingxiu¹ (AUTHOR) tangpingxiu@whu.edu.cn

Superior Title: Scientific Reports. 4/28/2024, Vol. 14 Issue 1, p1-8. 8p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *HEARING disorders

Company/Entity: UNITED States. Food & Drug Administration

Zugang prüfen (DOI)

8

Academic Journal

Topical Treatments in Atopic Dermatitis: An Expansive Review.

Authors: Lazar, Michelle¹ (AUTHOR), Zhang, Aurore D.¹ (AUTHOR), Vashi, Neelam A.¹ (AUTHOR) nvashi@bu.edu

Superior Title: Journal of Clinical Medicine. Apr2024, Vol. 13 Issue 8, p2185. 19p.

Subject Terms: *ATOPIC dermatitis, *PHOSPHODIESTERASE inhibitors, *TREATMENT effectiveness, *QUALITY of life, *INFLAMMATION, *IMPOTENCE

Zugang prüfen (DOI)

9

Academic Journal

Safety, Tolerability, and Pharmacokinetics of a Novel Oral Phosphodiesterase 4 Inhibitor, ME3183: First‐in‐Human Phase 1 Study.

Authors: Kato, Seiji¹ (AUTHOR) seiji.katou.aa@meiji.com, Cho, Naoki¹ (AUTHOR) naoki.chou@meiji.com, Koresawa, Tomokazu² (AUTHOR), Otake, Kazunari² (AUTHOR), Kano, Akiko¹ (AUTHOR)

Superior Title: Clinical Pharmacology in Drug Development. Apr2024, Vol. 13 Issue 4, p341-348. 8p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *PHARMACOKINETICS, *APREMILAST, *DRUG efficacy, *ATOPIC dermatitis

Zugang prüfen (DOI)

10

Academic Journal

The PDE4 Inhibitors Roflumilast and Rolipram Rescue ADO2 Osteoclast Resorption Dysfunction.

Authors: Hong, Jung Min¹ (AUTHOR), Gerard-O'Riley, Rita L.² (AUTHOR), Acton, Dena² (AUTHOR), Alam, Imranul² (AUTHOR), Econs, Michael J.^2,3 (AUTHOR), Bruzzaniti, Angela¹ (AUTHOR) abruzzan@iu.edu

Superior Title: Calcified Tissue International. Apr2024, Vol. 114 Issue 4, p430-443. 14p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *FORSKOLIN, *ADENYLATE cyclase, *CHLORIDE channels, *BONE resorption, *MISSENSE mutation, *ANIMAL rescue

Zugang prüfen (DOI)

11

Academic Journal

Themanagement of erectile dysfunction in menwith diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors.

Authors: Cayetano-Alcaraz, Axel Alberto¹ draxelcayetano@andrologia.com.mx, Tharakan, Tharu¹, Runzhi Chen², Sofikitis, Nikolaos³, Minhas, Suks¹

Superior Title: Andrology. Feb2023, Vol. 11 Issue 2, p257-269. 13p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *IMPOTENCE, *DIABETES, *PEOPLE with diabetes, *METABOLIC disorders

PDF Full Text

12

Academic Journal

The efficacy of PDE5 inhibitors in diabetic patients.

Authors: Swiecicka, Agnieszka¹ mitsides.a@unic.ac.cy

Superior Title: Andrology. Feb2023, Vol. 11 Issue 2, p245-256. 12p.

Subject Terms: *PHOSPHODIESTERASE-5 inhibitors, *PHOSPHODIESTERASE inhibitors, *PEOPLE with diabetes, *DIABETES complications, *CARDIOVASCULAR diseases

PDF Full Text

13

Academic Journal

Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.

Authors: Benza, Raymond L.¹ (AUTHOR) raymond.benza@osumc.edu, Franco, Veronica¹ (AUTHOR), Aras, Mandar A.² (AUTHOR), Spikes, Leslie³ (AUTHOR), Grinnan, Daniel⁴ (AUTHOR), Satler, Carol⁵ (AUTHOR)

Superior Title: Respiratory Research. 12/16/2022, Vol. 23 Issue 1, p1-10. 10p.

Subject Terms: *PULMONARY arterial hypertension, *PHOSPHODIESTERASE inhibitors, *EXERCISE tests, *INHALATION injuries, *VASCULAR resistance, *EXPERIMENTAL design

Geographic Terms: PALO Alto (Calif.)

HTML Full Text PDF Full Text

14

Academic Journal

PDE5 inhibitors and male reproduction: Is there a place for PDE5 inhibitors in infertility clinics or andrology laboratories?

Authors: Dimitriadis, Fotios¹ (AUTHOR), Kaltsas, Aris² (AUTHOR), Zachariou, Athanasios² (AUTHOR), Mamoulakis, Charalampos³ (AUTHOR), Tsiampali, Chara² (AUTHOR), Giannakis, Ioannis² (AUTHOR), Paschopoulos, Minas⁴ (AUTHOR), Papatsoris, Athanasios⁵ (AUTHOR), Loutradis, Dimitrios⁶ (AUTHOR), Tsounapi, Panagiota⁷ (AUTHOR), Takenaka, Atsushi⁷ (AUTHOR), Sofikitis, Nikolaos^2,7 (AUTHOR) akrosnin@hotmail.com

Superior Title: International Journal of Urology. Dec2022, Vol. 29 Issue 12, p1405-1418. 14p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *PHOSPHODIESTERASE-5 inhibitors, *FERTILITY clinics, *SERTOLI cells, *LEYDIG cells

HTML Full Text PDF Full Text

15

Academic Journal

Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia.

Authors: Al-Nema, Mayasah¹ (AUTHOR), Gaurav, Anand¹ (AUTHOR) anand.pharma@gmail.com, Lee, Ming Tatt^1,2,3 (AUTHOR), Okechukwu, Patrick⁴ (AUTHOR), Nimmanpipug, Piyarat^5,6 (AUTHOR), Lee, Vannajan Sanghiran⁷ (AUTHOR) anand.pharma@gmail.com

Superior Title: PLoS ONE. 12/1/2022, Vol. 17 Issue 12, p1-17. 17p.

Subject Terms: *ARIPIPRAZOLE, *PHOSPHODIESTERASE inhibitors, *CYCLIC adenylic acid, *CYCLIC guanylic acid, *ANIMAL disease models, *ACUTE toxicity testing, *DOPAMINE receptors

HTML Full Text PDF Full Text

16

Academic Journal

A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios.

Authors: Tosstorff, Andreas¹ (AUTHOR) a.tosstorff@gmail.com, Rudolph, Markus G.¹ (AUTHOR), Cole, Jason C.² (AUTHOR), Reutlinger, Michael¹ (AUTHOR), Kramer, Christian¹ (AUTHOR), Schaffhauser, Hervé¹ (AUTHOR), Nilly, Agnès¹ (AUTHOR), Flohr, Alexander¹ (AUTHOR), Kuhn, Bernd¹ (AUTHOR)

Superior Title: Journal of Computer-Aided Molecular Design. Oct2022, Vol. 36 Issue 10, p753-765. 13p.

Subject Terms: *DRUG discovery, *PHOSPHODIESTERASE inhibitors, *CLASSROOM environment, *DATA quality, *EXTRAPOLATION, *MACHINE learning

HTML Full Text PDF Full Text

17

Academic Journal

Trifluoromethyl Rhodium‐Carbynoid in [2+1+2] Cycloadditions.

Authors: Zhao, Wen‐Wen¹ (AUTHOR), Tian, Meng‐Yang¹ (AUTHOR), Zhou, Yi‐Lin¹ (AUTHOR), Liu, Lu‐Jie¹ (AUTHOR), Tian, Shao‐Fang¹ (AUTHOR), He, Chun‐Yang^1,2 (AUTHOR), Yang, Xing‐Zhi³ (AUTHOR), Chen, Yong‐Zheng^1,2 (AUTHOR), Han, Wen‐Yong^1,2 (AUTHOR) hanwy@126.com

Superior Title: Angewandte Chemie. Mar2024, Vol. 136 Issue 13, p1-7. 7p.

Subject Terms: *PHOSPHODIESTERASE inhibitors, *PHARMACEUTICAL chemistry, *RING formation (Chemistry), *HETEROARENES, *ANTINEOPLASTIC agents, *IMIDAZOPYRIDINES, *NITRILE oxides

Zugang prüfen (DOI)

18

Academic Journal

Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method.

Authors: Shao, Li¹ (AUTHOR), Mo, Jiajia¹ (AUTHOR), Xu, Qinlong¹ (AUTHOR), He, Guangwei¹ (AUTHOR), Xing, Chunyu² (AUTHOR), Chu, Zhaoxing¹ (AUTHOR) chuzhaoxing@163.com