Search Results - Kyeong Lee

1

Academic Journal

Utilizing machine learning to identify nifuroxazide as an inhibitor of ubiquitin-specific protease 21 in a drug repositioning strategy

Authors: Jihoon Tak, Tan Khanh Nguyen, Kyeong Lee, Sang Geon Kim, Hee-Chul Ahn

Superior Title: Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116459- (2024)

Subject Terms: Ubiquitin-specific protease 21 (USP21), Nifuroxazide, miR-4458, ATP citrate lyase (ACLY), AMP-activated protein kinase (AMPK), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0753332224003433; https://doaj.org/toc/0753-3322

Access URL: https://doaj.org/article/cf4d82f73e0643c9b1fdbc09f690ff0f

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2

Academic Journal

Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast CancerDesign, Synthesis, and In Vitro Evaluation

Authors: Hossam Nada, Anam Rana Gul, Ahmed Elkamhawy, Sungdo Kim, Minkyoung Kim, Yongseok Choi, Tae Jung Park, Kyeong Lee

Superior Title: ACS Omega, Vol 8, Iss 35, Pp 31784-31800 (2023)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/e3a4e0934ac24d6cadc6a2241bfd4092

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3

Academic Journal

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Authors: Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee, Ahmed A. Al-Karmalawy

Superior Title: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: Molecular hybridisation, selenium nanoparticles, dual Topo I/II inhibitors, cytotoxicity, apoptosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/a5000753091f4c2a97400dcb0e5c3430

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4

Academic Journal

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines

Authors: Seohyun Son, Ahmed Elkamhawy, Anam Rana Gul, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Ahmed Abdeen, Samah F. Ibrahim, Saud O. Alshammari, Qamar A. Alshammari, Won Jun Choi, Tae Jung Park, Kyeong Lee

Superior Title: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Subject Terms: EGFR/HER2, chemical synthesis, apoptosis, kinase panel, prostate carcinoma, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/303cf69ce9a44cd7b3453b78a9233a03

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5

Academic Journal

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies

Authors: Hossam Nada, Ahmed Elkamhawy, Magda H. Abdellattif, Andrea Angeli, Chang Hoon Lee, Claudiu T. Supuran, Kyeong Lee

Superior Title: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 994-1004 (2022)

Subject Terms: Quinazoline-benzenesulfonamide hybrids, Suzuki coupling, Carbonic anhydrase inhibitors, Molecular docking, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/23a2051a84c34794a63961386609c546

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6

Academic Journal

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis

Superior Title: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f7b60731b1ef420298a16914d07b8a55

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7

Academic Journal

Cantharidin-Based Verbenone Derivatives as a Novel Insecticide against Plutella xylostella: Design, Synthesis, Insecticidal Activity Evaluation, and 3D QSAR Study

Authors: Kwanshik Lee, Hossam Nada, Minkyoung Kim, Hyejun Park, Kiho Lee, Dongho Seo, Kyeong Lee, Yongseok Choi

Superior Title: Biomolecules, Vol 13, Iss 8, p 1272 (2023)

Subject Terms: verbenone, cantharidin, insecticide, diamondback moth, synthesis, 3D QSAR, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/13/8/1272; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/50b40af485d44fd89ede4f494eaf2a9a

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8

Academic Journal

Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations

Authors: Hossam Nada, Ahmed Elkamhawy, Kyeong Lee

Superior Title: PeerJ, Vol 10, p e14120 (2022)

Subject Terms: E-pharmacophore modeling, Structure-based virtual screening (SBVS), Molecular dynamics (MD) simulation, SARS-Cov-2 Mpro, Free energy calculations, Medicine

File Description: electronic resource

Relation: https://peerj.com/articles/14120.pdf; https://peerj.com/articles/14120/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/d9ddb596033f47c7845da58f0ca39dc5

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9

Academic Journal

Integration of Hybridization Strategies in Pyridine–Urea Scaffolds for Novel Anticancer Agents: Design, Synthesis, and Mechanistic Insights

Authors: Sreenivasulu Godesi, Hossam Nada, Joohan Lee, Joon-Hee Kang, Soo-Youl Kim, Yongseok Choi, Kyeong Lee

Superior Title: Molecules, Vol 28, Iss 13, p 4952 (2023)

Subject Terms: hybridization strategy, pyridine–urea, anticancer agents, molecular docking, molecular dynamics, MM–GBSA, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/13/4952; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/89e2dd38bdae41cfa6c7cc6eeb995e4f

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10

Academic Journal

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR)

Authors: Sreenivasulu Godesi, Joohan Lee, Hossam Nada, Guofeng Quan, Ahmed Elkamhawy, Yongseok Choi, Kyeong Lee

Superior Title: International Journal of Molecular Sciences, Vol 24, Iss 11, p 9450 (2023)

Subject Terms: c-KIT, GISTs, stem cell growth factor, c-KIT inhibitors, SAR, SCFR, Biology (General), QH301-705.5, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/1422-0067/24/11/9450; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

Access URL: https://doaj.org/article/1cf1e53732c047d0924763ff74593625

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11

Academic Journal

Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment

Authors: Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won, Kyeong Lee

Superior Title: Pharmaceuticals, Vol 16, Iss 5, p 683 (2023)

Subject Terms: MDH1/2, inhibitors, HIF-1α, lung cancer, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/5/683; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/8a1985dd73694d9e97e63647fd7dfd2c

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12

Academic Journal

Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations

Authors: Ahmed Elkamhawy, Na Kyoung Oh, Noha A. Gouda, Magda H. Abdellattif, Saud O. Alshammari, Mohammed A. S. Abourehab, Qamar A. Alshammari, Amany Belal, Minkyoung Kim, Ahmed A. Al-Karmalawy, Kyeong Lee

Superior Title: Metabolites, Vol 13, Iss 2, p 141 (2023)

Subject Terms: bioactive molecules, oxidative stress, antioxidant activity, indole, caffeic acid, DPPH, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/2/141; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/60740b90e2f640569454d315f108e5a3

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13

Academic Journal

New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights

Authors: Ahmed Elkamhawy, Eslam M. H. Ali, Kyeong Lee

Superior Title: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1572-1600 (2021)

Subject Terms: lck inhibitors, structure-activity relationship (sar), src family kinase, lymphocyte-specific protein tyrosine kinase (lck), molecular modelling, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/d6a27ac3eecf47fda47655e77608feac

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14

Academic Journal

Hypoxia-Inducible Factor-1: A Novel Therapeutic Target for the Management of Cancer, Drug Resistance, and Cancer-Related Pain

Authors: Bich Phuong Bui, Phuong Linh Nguyen, Kyeong Lee, Jungsook Cho

Superior Title: Cancers, Vol 14, Iss 24, p 6054 (2022)

Subject Terms: hypoxia, hypoxia-inducible factor-1 (HIF-1), tumor microenvironment, drug resistance, cancer-related pain, HIF-1 inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6694/14/24/6054; https://doaj.org/toc/2072-6694

Access URL: https://doaj.org/article/ff1978fb63514629ad446cecbe6aa7c9

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15

Academic Journal

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

Authors: Ahmed Elkamhawy, Seohyun Son, Hwa Young Lee, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Saud O. Alshammari, Abeer A. Abdelhameed, Qamar A. Alshammari, Ahmed Abdeen, Samah F. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Radwan Alnajjar, Won Jun Choi, Ahmed A. Al-Karmalawy, Kyeong Lee

Superior Title: Pharmaceuticals, Vol 16, Iss 1, p 43 (2022)

Subject Terms: nitro group containing drugs, antiproliferative activity, EGFR/HER2 dual inhibition, synthesis, kinase panel, lapatinib, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/1/43; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/373bf5a6def6412094a0e8a1752921b6

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16

Academic Journal

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Authors: Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park, Eun Joo Roh

Superior Title: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1568-1580 (2020)

Subject Terms: monoamine oxidase b, carboxamide, mao-b inhibitor, microwave synthesis, molecular modelling, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/dbd0beecfde24674a5c60b6407638e97

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17

Academic Journal

Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome

Authors: Jeong-Oh Shin, Jieun Song, Han Seul Choi, Jisu Lee, Kyeong Lee, Hyuk Wan Ko, Jinwoong Bok

Superior Title: EBioMedicine, Vol 49, Iss , Pp 305-317 (2019)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396419306796; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/ce90877efd73406c872860a8c5b772a3

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18

Academic Journal

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies

Authors: Ahmed Elkamhawy, Sora Paik, Eslam M. H. Ali, Ahmed H. E. Hassan, So Jin Kang, Kyeong Lee, Eun Joo Roh

Superior Title: Pharmaceuticals, Vol 15, Iss 9, p 1050 (2022)

Subject Terms: death-associated protein kinase 1 (DAPK1), kinase inhibitors, DAPK1 inhibitors, anti-proliferative activity, aryl carboxamides, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/9/1050; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/fedb93e85f274849ae9399ee5c901d26

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19

Academic Journal

Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin

Authors: Phuong Linh Nguyen, Ahmed Elkamhawy, Young Hee Choi, Chang Hoon Lee, Kyeong Lee, Jungsook Cho

Superior Title: International Journal of Molecular Sciences, Vol 23, Iss 17, p 9903 (2022)

Subject Terms: indole-based benzenesulfonamide, carbonic anhydrase inhibitor, anticancer effect, antimigration, doxorubicin, combination therapy, Biology (General), QH301-705.5, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/1422-0067/23/17/9903; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

Access URL: https://doaj.org/article/2518a8d8237144059350b31ce59bd65b

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20

Academic Journal

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

Superior Title: Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-14 (2019)

Subject Terms: Medicine, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413

Access URL: https://doaj.org/article/590b138997084a14a74110e5433070ff

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