Authors: Copmans, Daniëlle, Kildgaard, Sara, Roux, Emma, Partoens, Michèle, Steurs, Gert, Wang, Xinhui, De Borggraeve, Wim M., Esguerra, Camila V., Crawford, Alexander D., Larsen, Thomas O., de Witte, Peter A. M.
Superior Title: Copmans , D , Kildgaard , S , Roux , E , Partoens , M , Steurs , G , Wang , X , De Borggraeve , W M , Esguerra , C V , Crawford , A D , Larsen , T O & de Witte , P A M 2022 , ' From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin ' , Pharmaceuticals , vol. 15 , no. 2 , 247 . https://doi.org/10.3390/ph15020247
Subject Terms: Marine natural products, Drug discovery, Epilepsy, Zebrafish, Plinabulin, Halimide, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
File Description: application/pdf
Authors: Copmans, Daniëlle, Kildgaard, Sara, Rasmussen, Silas Anselm, Ślezak, Monika, Dirkx, Nina, Partoens, Michèle, Esguerra, Camila V., Crawford, Alexander D., Larsen, Thomas Ostenfeld, De Witte, Peter A.M.
Superior Title: Copmans , D , Kildgaard , S , Rasmussen , S A , Ślezak , M , Dirkx , N , Partoens , M , Esguerra , C V , Crawford , A D , Larsen , T O & De Witte , P A M 2019 , ' Zebrafish-based discovery of antiseizure compounds from the north sea: Isoquinoline alkaloids TMC-120A and TMC-120B ' , Marine Drugs , vol. 17 , no. 11 , 607 . https://doi.org/10.3390/md17110607
Subject Terms: PharmaSea, Epilepsy, Zebrafish, Marine drug discovery, Isoquinoline alkaloids, TMC-120A, TMC-120B, TMC-120C, Penicisochroman G, Ustusorane B
File Description: application/pdf
Authors: Copmans, Daniëlle, Rateb, Mostafa, Tabudravu, Jioji N, Pérez-Bonilla, Mercedes, Dirkx, Nina, Vallorani, Riccardo, Diaz, Caridad, Pérez Del Palacio, José, Smith, Alan J, Ebel, Rainer, Reyes, Fernando, Jaspars, Marcel, de Witte, Peter A M
Subject Terms: Aspergillus fumigatus, Epilepsy, antiseizure drug discovery, azaspirofuran A, marine drug discovery, pseurotin A2, Animals, Anticonvulsants, Brain, Cell Line, Drug Discovery, Drug Resistant Epilepsy, Electric Stimulation, Humans, Indian Ocean, Lactams, Male, Mice, Molecular Structure, Pyrrolidinones, Random Allocation, Seizures, Spiro Compounds, Zebrafish
Relation: http://hdl.handle.net/10668/12371; http://clok.uclan.ac.uk/22287/7/22287%20manuscript%20Copmans%20et%20al.%202018-02-08%20revised%202018-04-06.pdf
Authors: Sourbron, Jo, Schneider, Henning, Kecskés, Angéla, Liu, Yusu, Buening, Ellen M., Lagae, Lieven, Smolders, Ilse, de Witte, Peter
Superior Title: ACS CHEMICAL NEUROSCIENCE ; ISSN: 1948-7193
Subject Terms: Medicine and Health Sciences, Serotonergic receptors, pharmacological modulation, neurotransmitters, epilepsy, Dravet syndrome, zebrafish, MICROBORE LIQUID-CHROMATOGRAPHY, INHIBITORY INTERNEURONS, ANTIEPILEPTIC DRUGS, RECEPTOR LIGANDS, 5-HT1D RECEPTOR, AMINO-ACIDS, MOUSE MODEL, GUINEA-PIG, EXPRESSION
File Description: application/pdf
Relation: https://biblio.ugent.be/publication/8743762; http://hdl.handle.net/1854/LU-8743762; http://dx.doi.org/10.1021/acschemneuro.5b00342; https://biblio.ugent.be/publication/8743762/file/8743763
Authors: Leclercq, Karine, Afrikanova, Tatiana, Langlois, Melanie, De Prins, An, Buenafe, Olivia E., Rospo, Chiara C., Van Eeckhaut, Ann, de Witte, Peter A. M., Crawford, Alexander Dettmar, Smolders, Ilse, Esguerra, Camila V., Kaminski, Rafal M.
Superior Title: Epilepsy & behavior : E&B, 45, 53-63 (2015)
Subject Terms: Allylglycine, Animals, Anticonvulsants/therapeutic use, Diazepam/therapeutic use, Disease Models, Animal, Fructose/analogs & derivatives/therapeutic use, Male, Mice, Phenytoin/therapeutic use, Piracetam/analogs & derivatives/therapeutic use, Seizures/chemically induced/drug therapy, Treatment Outcome, Valproic Acid/therapeutic use, Zebrafish, Antiepileptic drugs, Epilepsy, Seizures, Treatment resistance, Human health sciences, Sciences de la santé humaine
Relation: urn:issn:1525-5050; urn:issn:1525-5069; https://orbilu.uni.lu/handle/10993/27274; info:hdl:10993/27274; https://orbilu.uni.lu/bitstream/10993/27274/1/Leclercq%20et%20al_Crawford.pdf; scopus-id:2-s2.0-84963936974; info:pmid:25845493; wos:000353830700010
Authors: Zhang, Yifan, Heylen, Lise, Partoens, Michèle, Mills, James D., Kaminski, Rafal M., Godard, Patrice, Gillard, Michel, de Witte, Peter A. M., Siekierska, Aleksandra
Superior Title: Frontiers in Molecular Neuroscience; 5/24/2022, p1-18, 18p
Subject Terms: DRUG discovery, ANTICONVULSANTS, EPILEPSY, GENE expression profiling, BRACHYDANIO
Authors: Heylen, Lise, Pham, Duc-Hung, De Meulemeester, Ann-Sofie, Samarut, Éric, Skiba, Adrianna, Copmans, Daniëlle, Kazwiny, Youcef, Vanden Berghe, Pieter, de Witte, Peter A. M., Siekierska, Aleksandra
Superior Title: Frontiers in Molecular Neuroscience; 10/14/2021, Vol. 14, p1-15, 15p
Authors: Siekierska, Aleksandra, Stamberger, Hannah, Deconinck, Tine, Oprescu, Stephanie N., Partoens, Michèle, Sourbron, Jo, Zhang, Yifan, Adriaenssens, Elias, Mullen, Patrick, Wiencek, Patrick, Hardies, Katja, Lee, Jeong-Soo, Giong, Hoi-Khoanh, Distelmaier, Felix, Elpeleg, Orly, Helbig, Katherine L., Hersh, Joseph, Isikay, Sedat, Jordan, Elizabeth, Karaca, Ender, Kecskes, Angela, Lupski, James R., Kovacs-Nagy, Reka, May, Patrick, Narayanan, Vinodh, Pendziwiat, Manuela, Ramsey, Keri, Rangasamy, Sampathkumar, Shinde, Deepali, Spiegel, Ronan, Timmerman, Vincent, Von Spiczak, Sarah, Helbig, Ingo, CARCD Research Group, EuroEPINOMICS RES AR working group, Balling, Rudi, Weckhuysen, Sarah, Francklyn, Christopher, Antonellis, Anthony, de Witte, Peter, De Jonghe, Peter
Contributors: Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group), Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group), ULHPC - University of Luxembourg: High Performance Computing
Superior Title: Nature Communications, 10 (1), 708 (2019-02-12)
Subject Terms: VARS, epilepsy, Aminoacyl tRNA synthetase, neurodevelopmental disease, recessive disease, Human health sciences, Neurology, Life sciences, Biochemistry, biophysics & molecular biology, Sciences de la santé humaine, Neurologie, Sciences du vivant, Biochimie, biophysique & biologie moléculaire
Relation: https://www.nature.com/articles/s41467-018-07953-w; urn:issn:2041-1723; https://orbilu.uni.lu/handle/10993/38801; info:hdl:10993/38801; scopus-id:2-s2.0-85061489358; info:pmid:30755616; wos:000458398900002
Authors: Copmans, Danielle, Orellana Paucar, Adriana Monserrath, Steurs, Gert, Zhang, Yifan, Ny, Annelii, Foubert, Kenn, Exarchou, Vasiliki, Siekierska, Aleksandra, Kim, Youngju, De borggraeve, Wim, Dehaen, Wim, Pieters, Luc, De Witte, Peter AM
Superior Title: Neurochemistry International
Subject Terms: EPILEPSY, DRUG DISCOVERY, METHYLATED FLAVONOIDS, NARINGENIN, ZEBRAFISH, MOUSE
File Description: application/pdf
Authors: Swaminathan, Amrutha, Hassan-Abdi, Rahma, Renault, Solène, Siekierska, Aleksandra, Riché, Raphaëlle, Liao, Meijiang, de Witte, Peter A.M., Soussi-Yanicostas, Nadia, Yanicostas, Constantin, Drapeau, Pierre, Samarut, Éric
Contributors: Université de Montréal (UdeM), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)
Superior Title: ISSN: 0960-9822.
Subject Terms: DEPDC5, GABA, epilepsy, mTOR, neurodevelopment, zebrafish, [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/29861134; hal-03451654; https://hal.science/hal-03451654; PUBMED: 29861134
Authors: Sourbron, Jo, Partoens, Michèle, Scheldeman, Chloë, Zhang, Yifan, Lagae, Lieven, Witte, Peter
Superior Title: Epilepsia (Series 4); Feb2019, Vol. 60 Issue 2, pe8-e13, 6p
Subject Terms: EFAVIRENZ, DRAVET syndrome, ANTICONVULSANTS, BRACHYDANIO, SYNDROMES, BIOLUMINESCENCE
Authors: Schubert, Julian, Siekierska, Aleksandra, Langlois, Mélanie, May, Patrick, Huneau, Clément, Becker, Felicitas, Muhle, Hiltrud, Suls, Arvid, Lemke, Johannes R, de Kovel, Carolien G F, Thiele, Holger, Konrad, Kathryn, Kawalia, Amit, Toliat, Mohammad R, Sander, Thomas, Rüschendorf, Franz, Caliebe, Almuth, Nagel, Inga, Kohl, Bernard, Kecskés, Angela, Jacmin, Maxime, Hardies, Katia, Weckhuysen, Sarah, Riesch, Erik, Dorn, Thomas, Brilstra, Eva H, Baulac, Stephanie, Møller, Rikke S, Hjalgrim, Helle, Koeleman, Bobby P C, Jurkat-Rott, Karin, Lehman-Horn, Frank, Roach, Jared C, Glusman, Gustavo, Hood, Leroy, Galas, David J, Martin, Benoit, de Witte, Peter A M, Biskup, Saskia, De Jonghe, Peter, Helbig, Ingo, Balling, Rudi, Nürnberg, Peter, Crawford, Alexander D, Esguerra, Camila V, Weber, Yvonne G, Lerche, Holger
Superior Title: Schubert , J , Siekierska , A , Langlois , M , May , P , Huneau , C , Becker , F , Muhle , H , Suls , A , Lemke , J R , de Kovel , C G F , Thiele , H , Konrad , K , Kawalia , A , Toliat , M R , Sander , T , Rüschendorf , F , Caliebe , A , Nagel , I , Kohl , B , Kecskés , A , Jacmin , M , Hardies , K , Weckhuysen , S , Riesch , ....
Subject Terms: Amino Acid Sequence, Animals, Codon, Nonsense, Cohort Studies, Comparative Genomic Hybridization, Epilepsy, Exome, Female, Gene Deletion, Genetic Linkage, Humans, In Situ Hybridization, Fluorescence, Male, Molecular Sequence Data, Mutation, Pedigree, Phenotype, Polymorphism, Single Nucleotide, Seizures, Febrile, Sequence Analysis, DNA, Syntaxin 1, Temperature, Zebrafish
Availability:
https://doi.org/10.1038/ng.3130
https://kclpure.kcl.ac.uk/portal/en/publications/mutations-in-stx1b-encoding-a-presynaptic-protein-cause-feverassociated-epilepsy-syndromes(9d6ba153-0bc6-4936-b0f9-ea0c6e9105dc).html
Authors: Vermoesen, Katia, Serruys, Ann-Sophie, Loyens, Ellen, Afrikanova, Tatiana, Massie, Ann, Schallier, Anneleen, Michotte, Yvette, Crawford, Alex, Esguerra, Camila, de Witte, Peter, Smolders, Ilse, Clinckers, Ralph
Subject Terms: antidepressants, anticonvulsant, proconvulsant, pilocarpine, pentylenetetrazole, mice, larval zebrafish, common pathogenic mechanisms, bupropion overdose, norepinephrine transporter, major depression, limbic seizures, epilepsy, citalopram, serotonin
Relation: Epilepsy & Behavior vol:22 issue:3 pages:450-460; https://lirias.kuleuven.be/handle/123456789/340472
Authors: Sourbron, Jo, Smolders, Ilse, de Witte, Peter, Lagae, Lieven
Superior Title: Frontiers in Pharmacology; 4/6/2017, Vol. 8, p1-13, 13p
Subject Terms: FENFLURAMINE, ANTICONVULSANTS, FISH mutation, THERAPEUTICS
Authors: Kozioł, Ewelina, Jóźwiak, Krzysztof, Budzyńska, Barbara, de Witte, Peter A. M., Copmans, Daniëlle, Skalicka-Woźniak, Krystyna
Superior Title: International Journal of Molecular Sciences; Nov2021, Vol. 22 Issue 21, p11420, 1p
Subject Terms: COUMARINS, COUMARIN derivatives, BRACHYDANIO, PLANT metabolites, METABOLITES, COMPARATIVE studies
Authors: de Witte, Peter1 peter.dewitte@kuleuven.be, Lagae, Lieven2
Superior Title: Brain: A Journal of Neurology. Jun2017, Vol. 140 Issue 6, p1-2. 2p.
Subject Terms: *BRAIN disease treatment, *ANTICONVULSANTS, *SEROTONINERGIC mechanisms, *SEIZURES (Medicine), *EPILEPSY, *HETEROCYCLIC compounds, *SEROTONIN, *SPASMS
Authors: Hotterbeekx, An1 (AUTHOR) an.hotterbeekx@uantwerpen.be, Raimon, Stephen2 (AUTHOR) stephenraimon@gmail.com, Abd-Elfarag, Gasim3,4 (AUTHOR) gasim4u83@gmail.com, Carter, Jane Y.5 (AUTHOR) jcarter@iconnect.co.ke, Sebit, Wilson6 (AUTHOR) wilson.sebit@hotmail.com, Suliman, Abozer7 (AUTHOR) abozersuliman@gmail.com, Siewe Fodjo, Joseph Nelson1 (AUTHOR) josephnelson.siewefodjo@uantwerpen.be, De Witte, Peter8 (AUTHOR) peter.dewitte@kuleuven.be, Logora, Makoy Yibi9 (AUTHOR) morrelogora@yahoo.com, Colebunders, Robert1 (AUTHOR) robert.colebunders@uantwerpen.be, Kumar-Singh, Samir10 (AUTHOR) samir.kumar-singh@uantwerpen.be
Superior Title: International Journal of Infectious Diseases. Feb2020, Vol. 91, p119-123. 5p.
Subject Terms: *ONCHOCERCA volvulus, *CEREBROSPINAL fluid, *EPILEPSY, *LABORATORY zebrafish, *CENTRAL nervous system, *SEIZURES (Medicine)
Geographic Terms: SOUTH Sudan
Authors: Serra, Ines1,2 (AUTHOR) i.serra@pgr.reading.ac.uk, Scheldeman, Chloë1,3 (AUTHOR) chloe.scheldeman@kuleuven.be, Bazelot, Michael4 (AUTHOR) mbazelot@gwpharm.com, Whalley, Benjamin J.1,2 (AUTHOR) bwhalley@gwpharm.com, Dallas, Mark L.2 (AUTHOR) m.dallas@reading.ac.uk, de Witte, Peter A.M.3 (AUTHOR) peter.dewitte@kuleuven.be, Williams, Claire M.1 (AUTHOR) claire.williams@reading.ac.uk
Superior Title: Behavioural Brain Research. May2019, Vol. 363, p135-144. 10p.
Subject Terms: *TUBEROUS sclerosis, *RARE diseases, *EPILEPSY, *NONSENSE mutation, *CELL size
Authors: Liu, Maoxuan1,2 (AUTHOR) liumaoxuan2008@gmail.com, Copmans, Daniëlle3 (AUTHOR), Lu, Jing-Guang4 (AUTHOR), Yang, Ming-Rong4 (AUTHOR), Sourbron, Jo3 (AUTHOR), Ny, Annelii3 (AUTHOR), Jiang, Zhi-Hong4 (AUTHOR), de Witte, Peter A.M.1,3 (AUTHOR) peter.dewitte@kuleuven.be, Luyten, Walter1 (AUTHOR)
Superior Title: Journal of Ethnopharmacology. Mar2019, Vol. 232, p130-134. 5p.
Subject Terms: *DRUG therapy for convulsions, *ANIMAL experimentation, *AZEPINES, *BIOLOGICAL assay, *BRAIN, *EPILEPSY, *ETHANOL, *GLYCOSIDES, *HERBAL medicine, *MASS spectrometry, *MEDICINAL plants, *CHINESE medicine, *SPASMS, *PLANT extracts
Authors: Hunyadi, Borbála1,2 borbala.hunyadi@esat.kuleuven.be, Siekierska, Aleksandra3, Sourbron, Jo3, Copmans, Daniëlle3, de Witte, Peter A.M.3
Superior Title: Journal of Neuroscience Methods. Aug2017, Vol. 287, p13-24. 12p.
Subject Terms: *TREATMENT of epilepsy, *SPASMS, *BRAIN physiology, *HIGH throughput screening (Drug development), *LABORATORY zebrafish, *DIAGNOSIS