Authors: Pettitt, Stephen J.Aff4, Ryan, Colm J.Aff5, Lord, Christopher J.Aff4
Contributors: Rosen, Steven T., Series EditorAff1, Yap, Timothy A., editorAff2, Shapiro, Geoffrey I., editorAff3
Superior Title: Targeting the DNA Damage Response for Cancer Therapy. 186:13-23
Authors: Quigley, David, Alumkal, Joshi J, Wyatt, Alexander W, Kothari, Vishal, Foye, Adam, Lloyd, Paul, Aggarwal, Rahul, Kim, Won, Lu, Eric, Schwartzman, Jacob, Beja, Kevin, Annala, Matti, Das, Rajdeep, Diolaiti, Morgan, Pritchard, Colin, Thomas, George, Tomlins, Scott, Knudsen, Karen, Lord, Christopher J, Ryan, Charles, Youngren, Jack, Beer, Tomasz M, Ashworth, Alan, Small, Eric J, Feng, Felix Y
Superior Title: Cancer Discovery, vol 7, iss 9
Subject Terms: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Cancer, Prostate Cancer, Genetics, Urologic Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Antineoplastic Agents, BRCA2 Protein, Cell-Free Nucleic Acids, DNA Copy Number Variations, Drug Resistance, Neoplasm, Germ-Line Mutation, Humans, Male, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerase Inhibitors, Prostatic Neoplasms, Exome Sequencing, Biochemistry and cell biology
Subject Geographic: 999 - 1005
File Description: application/pdf
Relation: qt9rz5j6xg; https://escholarship.org/uc/item/9rz5j6xg
Availability: https://escholarship.org/uc/item/9rz5j6xg
Authors: Mateo, Joaquin, Carreira, Suzanne, Sandhu, Shahneen, Miranda, Susana, Mossop, Helen, Perez-Lopez, Raquel, Nava Rodrigues, Daniel, Robinson, Dan, Omlin, Aurelius, Tunariu, Nina, Boysen, Gunther, Porta, Nuria, Flohr, Penny, Gillman, Alexa, Figueiredo, Ines, Paulding, Claire, Seed, George, Jain, Suneil, Ralph, Christy, Protheroe, Andrew, Hussain, Syed, Jones, Robert, Elliott, Tony, McGovern, Ursula, Bianchini, Diletta, Goodall, Jane, Zafeiriou, Zafeiris, Williamson, Chris T, Ferraldeschi, Roberta, Riisnaes, Ruth, Ebbs, Bernardette, Fowler, Gemma, Roda, Desamparados, Yuan, Wei, Wu, Yi-Mi, Cao, Xuhong, Brough, Rachel, Pemberton, Helen, A'Hern, Roger, Swain, Amanda, Kunju, Lakshmi P, Eeles, Rosalind, Attard, Gerhardt, Lord, Christopher J, Ashworth, Alan, Rubin, Mark A, Knudsen, Karen E, Feng, Felix Y, Chinnaiyan, Arul M, Hall, Emma, de Bono, Johann S
Superior Title: Mateo , J , Carreira , S , Sandhu , S , Miranda , S , Mossop , H , Perez-Lopez , R , Nava Rodrigues , D , Robinson , D , Omlin , A , Tunariu , N , Boysen , G , Porta , N , Flohr , P , Gillman , A , Figueiredo , I , Paulding , C , Seed , G , Jain , S , Ralph , C , Protheroe , A , Hussain , S , Jones , R , Elliott , T , McGovern , U , Bianchini , ....
Subject Terms: Adult, Aged, Anemia, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, DNA Repair, Drug Resistance, Neoplasm, Enzyme Inhibitors, Fatigue, Genes, BRCA2, Tumor Suppressor, Humans, Male, Middle Aged, Mutation, Neoplasm Metastasis, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerase Inhibitors, Prostatic Neoplasms, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
File Description: application/pdf
Authors: Aarts, Marieke, Bajrami, Ilirjana, Herrera-Abreu, Maria T, Elliott, Richard, Brough, Rachel, Ashworth, Alan, Lord, Christopher J, Turner, Nicholas C
Superior Title: Molecular Cancer Therapeutics, vol 14, iss 4
Subject Terms: Orphan Drug, Hematology, Genetics, Pediatric, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Cell Cycle Proteins, Cell Line, Checkpoint Kinase 1, DNA Helicases, DNA Replication, DNA-Binding Proteins, Drug Resistance, Fanconi Anemia, Fanconi Anemia Complementation Group Proteins, Gene Expression, Homologous Recombination, Humans, Mitosis, Nuclear Proteins, Protein Kinase Inhibitors, Protein Kinases, Protein-Tyrosine Kinases, RNA Helicases, RNA Interference, RNA, Small Interfering, Stress
Subject Geographic: 865 - 876
File Description: application/pdf
Relation: qt76k1g3m1; https://escholarship.org/uc/item/76k1g3m1
Availability: https://escholarship.org/uc/item/76k1g3m1
Authors: Watkins, Johnathan, Weekes, Daniel, Shah, Vandna, Gazinska, Patrycja, Joshi, Shalaka, Sidhu, Bhavna, Gillett, Cheryl, Pinder, Sarah, Vanoli, Fabio, Jasin, Maria, Mayrhofer, Markus, Isaksson, Anders, Cheang, Maggie CU, Mirza, Hasan, Frankum, Jessica, Lord, Christopher J, Ashworth, Alan, Vinayak, Shaveta, Ford, James M, Telli, Melinda L, Grigoriadis, Anita, Tutt, Andrew NJ
Superior Title: Cancer Discovery, vol 5, iss 5
Subject Terms: Human Genome, Cancer, Biotechnology, Genetics, Breast Cancer, 2.1 Biological and endogenous factors, Aetiology, Allelic Imbalance, Antineoplastic Combined Chemotherapy Protocols, Cell Cycle Proteins, Cell Line, Tumor, Cell Nucleus, Cell Survival, Chromosomal Instability, Cluster Analysis, DNA Copy Number Variations, Drug Resistance, Neoplasm, Gene Expression, Gene Expression Profiling, Gene Silencing, Genomics, Homologous Recombination, Humans, Platinum, Polymorphism, Single Nucleotide, RNA, Small Interfering
Subject Geographic: 488 - 505
File Description: application/pdf
Relation: qt4k91n7q7; https://escholarship.org/uc/item/4k91n7q7
Availability: https://escholarship.org/uc/item/4k91n7q7
Authors: Kwon, Yeon-Jin, Petrie, Kevin, Leibovitch, Boris A, Zeng, Lei, Mezei, Mihaly, Howell, Louise, Gil, Veronica, Christova, Rossitza, Bansal, Nidhi, Yang, Shuai, Sharma, Rajal, Ariztia, Edgardo V, Frankum, Jessica, Brough, Rachel, Sbirkov, Yordan, Ashworth, Alan, Lord, Christopher J, Zelent, Arthur, Farias, Eduardo, Zhou, Ming-Ming, Waxman, Samuel
Superior Title: Molecular Cancer Therapeutics, vol 14, iss 8
Subject Terms: Cancer, Stem Cell Research - Nonembryonic - Non-Human, Breast Cancer, Stem Cell Research, Genetics, Biotechnology, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, Animals, Antigens, CD, Antiparasitic Agents, Cadherins, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Drug Resistance, Neoplasm, Estrogen Receptor alpha, Female, Gene Expression Regulation, Neoplastic, Humans, Ivermectin, Mice, Models
Time: 1824 - 1836
File Description: application/pdf
Relation: qt0pg1v3ws; https://escholarship.org/uc/item/0pg1v3ws
Availability: https://escholarship.org/uc/item/0pg1v3ws
Authors: Gao, Shan, Bajrami, Ilirjana, Verrill, Clare, Kigozi, Asha, Ouaret, Djamila, Aleksic, Tamara, Asher, Ruth, Han, Cheng, Allen, Paul, Bailey, Deborah, Feller, Stephan, Kashima, Takeshi, Athanasou, Nicholas, Blay, Jean-Yves, Schmitz, Sandra, Machiels, Jean-Pascal, Upile, Nav, Jones, Terry M, Thalmann, George, Ashraf, Shazad Q, Wilding, Jennifer L, Bodmer, Walter F, Middleton, Mark R, Ashworth, Alan, Lord, Christopher J, Macaulay, Valentine M
Contributors: UCL - (SLuc) Centre du cancer, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'oto-rhino-laryngologie
Superior Title: Cancer research, Vol. 74, no.20, p. 5866-77 (2014)
Subject Terms: Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Carcinoma, Squamous Cell, Cell Line, Tumor, Dishevelled Proteins, Drug Resistance, Neoplasm, Gene Expression, Head and Neck Neoplasms, Humans, Inhibitory Concentration 50, Insulin-Like Growth Factor I, Isoxazoles, MAP Kinase Signaling System, Male, Mice, Phosphoproteins, Pyrimidines, Receptor, IGF Type 1, Wnt Proteins, Xenograft Model Antitumor Assays, ras Proteins
Relation: boreal:245573; http://hdl.handle.net/2078.1/245573; info:pmid/25168481; urn:EISSN:1538-7445
Authors: Shen, Yuqiao, Rehman, Farah L, Feng, Ying, Boshuizen, Julia, Bajrami, Ilirjana, Elliott, Richard, Wang, Bing, Lord, Christopher J, Post, Leonard E, Ashworth, Alan
Superior Title: Clinical Cancer Research, vol 19, iss 18
Subject Terms: Cancer, Orphan Drug, Rare Diseases, Genetics, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Blotting, Western, Breast Neoplasms, Cell Proliferation, DNA Repair-Deficiency Disorders, Drug Resistance, Neoplasm, Female, Flow Cytometry, Humans, Mice, Nude, Phthalazines, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, RNA, Small Interfering, Rats, Tumor Cells, Cultured, Tumor Stem Cell Assay, Xenograft Model Antitumor Assays
Time: 5003 - 5015
File Description: application/pdf
Relation: qt9p46v2pv; https://escholarship.org/uc/item/9p46v2pv
Availability: https://escholarship.org/uc/item/9p46v2pv
Authors: Khalique, Saira, Pettitt, Stephen J, Kelly, Ger, Tunariu, Nina, Natrajan, Rachael, Banerjee, Susana, Lord, Christopher J
Superior Title: Journal of Pathology: Clinical Research; Jan2020, Vol. 6 Issue 1, p3-11, 9p
Authors: Barazas, Marco, Annunziato, Stefano, Pettitt, Stephen J., de Krijger, Inge, Ghezraoui, Hind, Roobol, Stefan J., Lutz, Catrin, Frankum, Jessica, Song, Fei Fei, Brough, Rachel, Evers, Bastiaan, Gogola, Ewa, Bhin, Jinhyuk, van de Ven, Marieke, van Gent, Dik C., Jacobs, Jacqueline J.L., Chapman, Ross, Lord, Christopher J., Jonkers, Jos, Rottenberg, Sven
Superior Title: Cell Reports; May2018, Vol. 23 Issue 7, p2107-2118, 12p
Authors: Lord, Christopher J.1 Chris.Lord@icr.ac.uk, Tutt, Andrew N.J.1 Andrew.Tutt@kcl.ac.uk, worth, Alan Ash1 Alan.Ashworth@icr.ac.uk
Superior Title: Annual Review of Medicine. 2015, Vol. 66 Issue 1, p455-470. 16p.
Subject Terms: *POLY(ADP-ribose) polymerase, *BRCA genes, *CANCER treatment, *GENE therapy, *GENETIC mutation, *CANCER genetics, *ENZYME inhibitors, *CELL death
Authors: Barber, Louise J, Sandhu, Shahneen, Chen, Lina, Campbell, James, Kozarewa, Iwanka, Fenwick, Kerry, Assiotis, Ioannis, Rodrigues, Daniel Nava, Reis-Filho, Jorge S, Moreno, Victor, Mateo, Joaquin, Molife, L Rhoda, De Bono, Johann, Kaye, Stan, Lord, Christopher J, Ashworth, Alan
Superior Title: Journal of Pathology; Feb2013, Vol. 229 Issue 3, p422-429, 8p
Authors: Edwards, Stacey L., Brough, Rachel, Lord, Christopher J., Natrajan, Rachael, Vatcheva, Radost, Levine, Douglas A., Boyd, Jeff, Reis-Filho, Jorge S., Ashworth, Alan
Superior Title: Nature; 2/28/2008, Vol. 451 Issue 7182, p1111-1115, 5p, 1 Diagram, 2 Charts, 3 Graphs
Subject Terms: GENETIC mutation, THERAPEUTICS, DNA damage, GENETIC recombination, HOMOLOGY (Biology), DRUG resistance, GENOMICS, CELLS, EXPERIMENTAL design
Authors: Harvey-Jones, E, Raghunandan, M, Robbez-Masson, L, Magraner-Pardo, L, Alaguthurai, T, Yablonovitch, A, Yen, J, Xiao, H, Brough, R, Frankum, J, Song, F, Yeung, J, Savy, T, Gulati, A, Alexander, J, Kemp, H, Starling, C, Konde, A, Marlow, R, Cheang, M, Proszek, P, Hubank, M, Cai, M, Trendell, J, Lu, R, Liccardo, R, Ravindran, N, Llop-Guevara, A, Rodriguez, O, Balmana, J, Lukashchuk, N, Dorschner, M, Drusbosky, L, Roxanis, I, Serra, V, Haider, S, Pettitt, SJ, Lord, CJ, Tutt, ANJ
Contributors: Song, Feifei, Yeung, Chit Sum Jason, Cheang, Chon, Haider, Syed, Lord, Christopher, Tutt, Andrew
Subject Terms: PARP inhibitors, breast cancer, drug resistance, homologous recombination deficiency, liquid biopsy, platinum
Subject Geographic: England
File Description: Print-Electronic; S0923-7534(24)00010-3 -; application/pdf
Relation: S0923-7534(24)00010-3; Annals of Oncology, 2024, pp. S0923-7534(24)00010-3 -; https://repository.icr.ac.uk/handle/internal/6173
Authors: Pettitt, SJ, Shao, N, Zatreanu, D, Frankum, J, Bajrami, I, Brough, R, Krastev, DB, Roumeliotis, TI, Choudhary, JS, Lorenz, S, Rust, A, de Bono, JS, Yap, TA, Tutt, ANJ, Lord, CJ
Contributors: Pettitt, Stephen, Krastev, Dragomir, Roumeliotis, Theodoros, Choudhary, Jyoti, De Bono, Johann, Tutt, Andrew, Lord, Christopher
Subject Terms: Humans, Female, Poly(ADP-ribose) Polymerase Inhibitors, Drug Resistance, Neoplasm, Antineoplastic Agents, BRCA1 Protein, BRCA2 Protein, Mutation, Neoplasms, Ovarian Neoplasms, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases
Subject Geographic: England
File Description: Print-Electronic; 2709; application/pdf
Relation: Oncogene, 2023, 42 (36), pp. 2701 - 2709; https://repository.icr.ac.uk/handle/internal/5981
Authors: Wicks, AJ, Krastev, DB, Pettitt, SJ, Tutt, ANJ, Lord, CJ
Contributors: Wicks, Andrew, Lord, Christopher
Subject Terms: PARP inhibitors, biomarkers, cancer, drug resistance, synthetic lethality, Neoplasm, Humans, Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors
Subject Geographic: England
File Description: Print-Electronic; application/pdf
Relation: Open Biology, 2022, 12 (7), pp. 220118 -; https://repository.icr.ac.uk/handle/internal/5437
Authors: Zatreanu, D, Robinson, HMR, Alkhatib, O, Boursier, M, Finch, H, Geo, L, Grande, D, Grinkevich, V, Heald, RA, Langdon, S, Majithiya, J, McWhirter, C, Martin, NMB, Moore, S, Neves, J, Rajendra, E, Ranzani, M, Schaedler, T, Stockley, M, Wiggins, K, Brough, R, Sridhar, S, Gulati, A, Shao, N, Badder, LM, Novo, D, Knight, EG, Marlow, R, Haider, S, Callen, E, Hewitt, G, Schimmel, J, Prevo, R, Alli, C, Ferdinand, A, Bell, C, Blencowe, P, Bot, C, Calder, M, Charles, M, Curry, J, Ekwuru, T, Ewings, K, Krajewski, W, MacDonald, E, McCarron, H, Pang, L, Pedder, C, Rigoreau, L, Swarbrick, M
Contributors: Haider, Syed, Pettitt, Stephen, Lord, Christopher
Subject Terms: Organoids, Cell Line, Tumor, Animals, Humans, Mice, Rats, Ovarian Neoplasms, DNA Damage, Deoxyribonucleases, DNA-Directed DNA Polymerase, Cell Cycle Proteins, DNA-Binding Proteins, BRCA1 Protein, BRCA2 Protein, Nucleic Acid Synthesis Inhibitors, Drug Screening Assays, Antitumor, Inhibitory Concentration 50, Apoptosis, Cell Proliferation, Cell Survival, DNA Repair, Allosteric Regulation, Drug Resistance, Neoplasm, Female, Homologous Recombination, Poly(ADP-ribose) Polymerase Inhibitors, Tumor Suppressor p53-Binding Protein 1
File Description: Electronic; ?; application/pdf
Relation: Nature communications, 2021, 12 (1), pp. 3636 - ?; https://repository.icr.ac.uk/handle/internal/4762
Authors: Quigley, D, Alumkal, JJ, Wyatt, AW, Kothari, V, Foye, A, Lloyd, P, Aggarwal, R, Kim, W, Lu, E, Schwartzman, J, Beja, K, Annala, M, Das, R, Diolaiti, M, Pritchard, C, Thomas, G, Tomlins, S, Knudsen, K, Lord, CJ, Ryan, C, Youngren, J, Beer, TM, Ashworth, A, Small, EJ, Feng, FY
Contributors: Lord, Christopher
Subject Terms: Humans, Prostatic Neoplasms, Piperazines, Phthalazines, BRCA2 Protein, Antineoplastic Agents, Drug Resistance, Neoplasm, Germ-Line Mutation, Male, DNA Copy Number Variations, Poly(ADP-ribose) Polymerase Inhibitors, Whole Exome Sequencing, Cell-Free Nucleic Acids
File Description: Print-Electronic; 1005; application/pdf
Relation: Cancer discovery, 2017, 7 (9), pp. 999 - 1005; https://repository.icr.ac.uk/handle/internal/4076
Authors: Pettitt, SJ, Krastev, DB, Brandsma, I, Dréan, A, Song, F, Aleksandrov, R, Harrell, MI, Menon, M, Brough, R, Campbell, J, Frankum, J, Ranes, M, Pemberton, HN, Rafiq, R, Fenwick, K, Swain, A, Guettler, S, Lee, J-M, Swisher, EM, Stoynov, S, Yusa, K, Ashworth, A, Lord, CJ
Contributors: Song, Feifei, Lord, Christopher, Guettler, Sebastian, Pettitt, Stephen, Campbell, James, Swain, Amanda, Krastev, Dragomir
Subject Terms: Cell Line, Tumor, Animals, Mice, Inbred BALB C, Humans, Nude, Neoplasms, Phthalazines, BRCA1 Protein, Xenograft Model Antitumor Assays, DNA Mutational Analysis, Mutagenesis, Zinc Fingers, Drug Resistance, Neoplasm, Point Mutation, Aged, Female, CRISPR-Cas Systems, Poly(ADP-ribose) Polymerase Inhibitors, Precision Medicine, Mouse Embryonic Stem Cells, Poly (ADP-Ribose) Polymerase-1, Whole Genome Sequencing
File Description: Electronic; ?; application/pdf
Relation: Nature communications, 2018, 9 (1), pp. 1849 - ?; https://repository.icr.ac.uk/handle/internal/1686
Authors: Barazas, M, Annunziato, S, Pettitt, SJ, de Krijger, I, Ghezraoui, H, Roobol, SJ, Lutz, C, Frankum, J, Song, FF, Brough, R, Evers, B, Gogola, E, Bhin, J, van de Ven, M, van Gent, DC, Jacobs, JJL, Chapman, R, Lord, CJ, Jonkers, J, Rottenberg, S
Contributors: Song, Feifei, Lord, Christopher, Pettitt, Stephen
Subject Terms: Cell Line, Tumor, Telomere, Animals, Mice, Disease Models, Animal, Multiprotein Complexes, BRCA1 Protein, Drug Resistance, Neoplasm, Female, DNA Breaks, Double-Stranded, CRISPR-Cas Systems, Poly(ADP-ribose) Polymerase Inhibitors, Mouse Embryonic Stem Cells
File Description: Print; 2118; application/pdf
Relation: Cell reports, 2018, 23 (7), pp. 2107 - 2118; https://repository.icr.ac.uk/handle/internal/1701