Authors: Lord, Christopher J, Ashworth, Alan

Superior Title: Science, vol 355, iss 6330

Subject Terms: Genetics, Cancer, 5.1 Pharmaceuticals, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Good Health and Well Being, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Antineoplastic Protocols, BRCA2 Protein, Clinical Trials as Topic, DNA Damage, DNA Repair, Germ-Line Mutation, Humans, Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Synthetic Lethal Mutations, Ubiquitin-Protein Ligases, General Science & Technology

Time: 1152 - 1158

File Description: application/pdf

Relation: qt00x5r9k4; https://escholarship.org/uc/item/00x5r9k4

Availability: https://escholarship.org/uc/item/00x5r9k4

Authors: Lord, Christopher J.¹, Ashworth, Alan¹

Superior Title: Nature. 1/19/2012, Vol. 481 Issue 7381, p287-294. 8p. 2 Diagrams, 1 Chart.

Subject Terms: *DNA damage, *CANCER treatment, *GENOMICS, *DNA repair, *PHENOTYPES, *NUCLEOTIDE sequence

Authors: Brough, Rachel, Bajrami, Ilirjana, Vatcheva, Radost, Natrajan, Rachael, Reis-Filho, Jorge S, Lord, Christopher J, Ashworth, Alan

Superior Title: EMBO Journal; 3/7/2012, Vol. 31 Issue 5, p1160-1176, 17p, 1 Color Photograph, 1 Diagram, 1 Chart, 5 Graphs

Subject Terms: BRCA proteins, CELL cycle, BREAST cancer treatment, CANCER chemotherapy, GENOMES, HEALTH outcome assessment, DNA damage

Authors: Lord, Christopher J., McDonald, Sarah, Swift, Sally¹, Turner, Nicholas C.¹, Ashworth, Alan Alan.Ashworth@icr.ac.uk

Superior Title: DNA Repair. Dec2008, Vol. 7 Issue 12, p2010-2019. 10p.

Subject Terms: *DNA repair, *POLY(ADP-ribose) polymerase, *CANCER treatment, *BREAST cancer research, *DNA damage, *GENETIC testing, *CLINICAL trials, *GENETICS

Authors: Edwards, Stacey L., Brough, Rachel, Lord, Christopher J., Natrajan, Rachael, Vatcheva, Radost, Levine, Douglas A., Boyd, Jeff, Reis-Filho, Jorge S., Ashworth, Alan

Superior Title: Nature; 2/28/2008, Vol. 451 Issue 7182, p1111-1115, 5p, 1 Diagram, 2 Charts, 3 Graphs

Subject Terms: GENETIC mutation, THERAPEUTICS, DNA damage, GENETIC recombination, HOMOLOGY (Biology), DRUG resistance, GENOMICS, CELLS, EXPERIMENTAL design

Authors: Martin, Sarah A¹, Lord, Christopher J¹, Ashworth, Alan¹ Alan.Ashworth@icr.ac.uk

Superior Title: Current Opinion in Genetics & Development. Feb2008, Vol. 18 Issue 1, p80-86. 7p.

Subject Terms: *DNA repair, *CANCER treatment, *ANTINEOPLASTIC agents, *DNA damage, *CANCER cells

Authors: Arias-Lopez, Carmen, Lazaro-Trueba, Iciar, Kerr, Peter, Lord, Christopher J., Dexter, Tim, Iravani, Marjan, Ashworth, Alan, Silva, Augusto

Superior Title: EMBO Reports; Feb2006, Vol. 7 Issue 2, p219-224, 6p, 1 Diagram, 3 Graphs

Subject Terms: GENOMES, HOMOLOGY (Biology), DNA repair, DNA damage, GENETIC mutation, MESSENGER RNA, GENES

Authors: Farmer, Hannah, McCabe, Nuala, Lord, Christopher J., Tutt, Andrew N. J., Johnson, Damian A., Richardson, Tobias B., Santarosa, Manuela, Dillon, Krystyna J., Hickson, Ian, Knights, Charlotte, Martin, Niall M. B., Jackson, Stephen P., Smith, Graeme C. M., Ashworth, Alan

Superior Title: Nature; 4/14/2005, Vol. 434 Issue 7035, p917-921, 5p

Subject Terms: DNA repair, DNA damage, BIOCHEMICAL genetics, GENETIC mutation, CANCER genetics, APOPTOSIS

Authors: Zelceski, A, Francica, P, Lingg, L, Mutlu, M, Stok, C, Liptay, M, Alexander, J, Baxter, JS, Brough, R, Gulati, A, Haider, S, Raghunandan, M, Song, F, Sridhar, S, Forment, JV, O'Connor, MJ, Davies, BR, van Vugt, MATM, Krastev, DB, Pettitt, SJ, Tutt, ANJ, Rottenberg, S, Lord, CJ

Contributors: Song, Feifei, Lord, Christopher

Subject Terms: CP: Molecular biology, DNA repair, MND1, PARP inhibitor, PSMC3IP, PSMC3IP and PARPi sensitivity, Poly(ADP-ribose) Polymerase Inhibitors, Antineoplastic Agents, DNA Damage, BRCA1 Protein, Recombinational DNA Repair, Cell Line, Tumor

Subject Geographic: United States

File Description: Print-Electronic; application/pdf

Relation: ARTN 112484; S2211-1247(23)00495-3; Cell Reports, 2023, 42 (5), pp. 112484 -; https://repository.icr.ac.uk/handle/internal/5918

Availability: https://doi.org/10.1016/j.celrep.2023.112484
https://repository.icr.ac.uk/handle/internal/5918

Authors: Zatreanu, D, Robinson, HMR, Alkhatib, O, Boursier, M, Finch, H, Geo, L, Grande, D, Grinkevich, V, Heald, RA, Langdon, S, Majithiya, J, McWhirter, C, Martin, NMB, Moore, S, Neves, J, Rajendra, E, Ranzani, M, Schaedler, T, Stockley, M, Wiggins, K, Brough, R, Sridhar, S, Gulati, A, Shao, N, Badder, LM, Novo, D, Knight, EG, Marlow, R, Haider, S, Callen, E, Hewitt, G, Schimmel, J, Prevo, R, Alli, C, Ferdinand, A, Bell, C, Blencowe, P, Bot, C, Calder, M, Charles, M, Curry, J, Ekwuru, T, Ewings, K, Krajewski, W, MacDonald, E, McCarron, H, Pang, L, Pedder, C, Rigoreau, L, Swarbrick, M

Contributors: Haider, Syed, Pettitt, Stephen, Lord, Christopher

Subject Terms: Organoids, Cell Line, Tumor, Animals, Humans, Mice, Rats, Ovarian Neoplasms, DNA Damage, Deoxyribonucleases, DNA-Directed DNA Polymerase, Cell Cycle Proteins, DNA-Binding Proteins, BRCA1 Protein, BRCA2 Protein, Nucleic Acid Synthesis Inhibitors, Drug Screening Assays, Antitumor, Inhibitory Concentration 50, Apoptosis, Cell Proliferation, Cell Survival, DNA Repair, Allosteric Regulation, Drug Resistance, Neoplasm, Female, Homologous Recombination, Poly(ADP-ribose) Polymerase Inhibitors, Tumor Suppressor p53-Binding Protein 1

File Description: Electronic; ?; application/pdf

Relation: Nature communications, 2021, 12 (1), pp. 3636 - ?; https://repository.icr.ac.uk/handle/internal/4762

Availability: https://doi.org/10.1038/s41467-021-23463-8
https://repository.icr.ac.uk/handle/internal/4762

Authors: Holme, H, Gulati, A, Brough, R, Fleuren, EDG, Bajrami, I, Campbell, J, Chong, IY, Costa-Cabral, S, Elliott, R, Fenton, T, Frankum, J, Jones, SE, Menon, M, Miller, R, Pemberton, HN, Postel-Vinay, S, Rafiq, R, Selfe, JL, von Kriegsheim, A, Munoz, AG, Rodriguez, J, Shipley, J, van der Graaf, WTA, Williamson, CT, Ryan, CJ, Pettitt, S, Ashworth, A, Strauss, SJ, Lord, CJ

Contributors: Campbell, James, Chong, Yu-Shing, Jones, Samuel, Selfe, Joanna, Shipley, Janet, Pettitt, Stephen, Lord, Christopher

Subject Terms: Cell Line, Tumor, Cell Nucleus, Humans, Osteosarcoma, DNA Damage, BRCA1 Protein, BRCA2 Protein, Drug Screening Assays, Antitumor, DNA Repair, Mutagenesis, Drug Resistance, Neoplasm, Mutation, Rad51 Recombinase, High-Throughput Screening Assays, CRISPR-Cas Systems, Datasets as Topic, Poly(ADP-ribose) Polymerase Inhibitors

File Description: Electronic; ?; application/pdf

Relation: Scientific reports, 2018, 8 (1), pp. 10614 - ?; https://repository.icr.ac.uk/handle/internal/2226

Availability: https://doi.org/10.1038/s41598-018-29043-z
https://repository.icr.ac.uk/handle/internal/2226

Authors: Naidoo, K, Wai, PT, Maguire, SL, Daley, F, Haider, S, Kriplani, D, Campbell, J, Mirza, H, Grigoriadis, A, Tutt, A, Moseley, PM, Abdel-Fatah, TMA, Chan, SYT, Madhusudan, S, Rhaka, EA, Ellis, IO, Lord, CJ, Yuan, Y, Green, AR, Natrajan, R

Contributors: Haider, Syed, Naidoo, Kalnisha, Natrajan, Rachael, Tutt, Andrew, Lord, Christopher, Campbell, James, Yuan, Yinyin

Subject Terms: Humans, Breast Neoplasms, DNA Damage, Cyclin-Dependent Kinases, Immunohistochemistry, Retrospective Studies, Middle Aged, Female, Biomarkers, Tumor

File Description: Print-Electronic; 315; application/pdf

Relation: Molecular cancer therapeutics, 2018, 17 (1), pp. 306 - 315; https://repository.icr.ac.uk/handle/internal/849

Availability: https://doi.org/10.1158/1535-7163.mct-17-0760
https://repository.icr.ac.uk/handle/internal/849

Authors: Nikkilä, J, Kumar, R, Campbell, J, Brandsma, I, Pemberton, HN, Wallberg, F, Nagy, K, Scheer, I, Vertessy, BG, Serebrenik, AA, Monni, V, Harris, RS, Pettitt, SJ, Ashworth, A, Lord, CJ

Contributors: Campbell, James, Lord, Christopher, Pettitt, Stephen

Subject Terms: Cell Line, Humans, DNA Damage, Cisplatin, Uracil, Cytidine Deaminase, Cell Cycle Proteins, Nuclear Proteins, Minor Histocompatibility Antigens, Blotting, Western, Gene Expression Regulation, Neoplastic, RNA Interference, Mutation, Tumor Suppressor Protein p53, Protein-Tyrosine Kinases, Gene Knockout Techniques, HEK293 Cells, Cell Cycle Checkpoints, G2 Phase Cell Cycle Checkpoints, Ataxia Telangiectasia Mutated Proteins, Checkpoint Kinase 2, CRISPR-Cas Systems, Poly(ADP-ribose) Polymerase Inhibitors, Checkpoint Kinase 1

File Description: Print-Electronic; 123; application/pdf

Relation: British journal of cancer, 2017, 117 (1), pp. 113 - 123; https://repository.icr.ac.uk/handle/internal/850

Availability: https://doi.org/10.1038/bjc.2017.133
https://repository.icr.ac.uk/handle/internal/850

Authors: Rouleau-Turcotte, Élise¹ (AUTHOR), Krastev, Dragomir B.² (AUTHOR), Pettitt, Stephen J.² (AUTHOR), Lord, Christopher J.² (AUTHOR), Pascal, John M.¹ (AUTHOR) john.pascal@umontreal.ca

Superior Title: Molecular Cell. Aug2022, Vol. 82 Issue 16, p2939-2939. 1p.

Subject Terms: *ADP-ribosylation, *POST-translational modification, *CATALYTIC domains, *DNA damage, *POLY(ADP-ribose) polymerase, *NAD (Coenzyme), *CRYSTAL structure

Authors: Neijenhuis, Sari¹, Bajrami, Ilirjana¹, Miller, Rowan¹, Lord, Christopher J.¹ Chris.Lord@icr.ac.uk, Ashworth, Alan¹ Alan.Ashworth@icr.ac.uk

Superior Title: DNA Repair. Jun2013, Vol. 12 Issue 6, p394-402. 9p.

Subject Terms: *MICRORNA, *POLY ADP ribose, *KILLER cells, *GENETIC regulation, *SENSITIVITY analysis, *DNA damage

Authors: Martin, Sarah A.^1,2, McCabe, Nuala^1,2, Mullarkey, Michelle³, Cummins, Robert³, Burgess, Darren J.^1,2, Nakabeppu, Yusaku⁴, Oka, Sugako⁴, Kay, Elaine³, Lord, Christopher J.² chris.lord@icr.ac.uk, Ashworth, Alan^1,2 alan.ashworth@icr.ac.uk

Superior Title: Cancer Cell. Mar2010, Vol. 17 Issue 3, p235-248. 14p.

Subject Terms: *CANCER treatment, *DNA polymerases, *TARGETED drug delivery, *TUMOR suppressor proteins, *MITOCHONDRIAL DNA, *CELL cycle, *DNA damage

Authors: Brough, Rachel^1,2, Wei, Debbie³, Leulier, Sophie^1,2, Lord, Christopher J.², Rong, Yikang S.³, Ashworth, Alan^1,2 Alan.Ashworth@icr.ac.uk

Superior Title: DNA Repair. Jan2008, Vol. 7 Issue 1, p10-19. 10p.

Subject Terms: *DROSOPHILA melanogaster, *DNA damage, *DNA repair, *DNA, *GENE conversion

Authors: Brandsma, I, Fleuren, EDG, Williamson, CT, Lord, CJ

Contributors: Lord, Christopher

Subject Terms: Animals, Humans, Neoplasms, DNA Damage, Antineoplastic Agents, Protein Kinase Inhibitors, Drug Design, Mutation, Molecular Targeted Therapy, Biomarkers, Poly(ADP-ribose) Polymerase Inhibitors

File Description: Print-Electronic; 1355; application/pdf

Relation: Expert opinion on investigational drugs, 2017, 26 (12), pp. 1341 - 1355; https://repository.icr.ac.uk/handle/internal/1071

Availability: https://doi.org/10.1080/13543784.2017.1389895
https://repository.icr.ac.uk/handle/internal/1071

Authors: Lord, CJ, Ashworth, A

Contributors: Lord, Christopher

Subject Terms: Humans, Neoplasms, DNA Damage, Ubiquitin-Protein Ligases, BRCA2 Protein, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Antineoplastic Protocols, DNA Repair, Germ-Line Mutation, Clinical Trials as Topic, Poly(ADP-ribose) Polymerase Inhibitors, Synthetic Lethal Mutations

File Description: Print-Electronic; 1158; application/pdf

Relation: Science (New York, N.Y.), 2017, 355 (6330), pp. 1152 - 1158; https://repository.icr.ac.uk/handle/internal/543

Availability: https://doi.org/10.1126/science.aam7344
https://repository.icr.ac.uk/handle/internal/543