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Dissertation/ Thesis

Subject Terms: combined with computer tomography (CT) and/or magnetic resonans (MRI) for this patient group. Objectives: Assessment of change in reconstruction matrix. Choice of modality at different Body Mass Index, SUVmax was interpolated to four selected timepoints. Results: There is a significant difference between the matrixes. Subjective visual assessment of the attenuated PET scans also showed a difference between the matrixes. At BMI <30 there was no significant difference in COV between PET/CT and PET/MRI. At group BMI >, 30 there was a significant difference between COV in PET/CT and PET/MRI. Based on average SUVmax it appears that SUVmax has a decreasing trend between 120 and 240 minutes. Conclusion: based on our results, ABSTRACT The background for the thesis was the initiation of a new study at St Olavs hospital for patients diagnosed with prostate cancer. The aim of the thesis is a proposal standardized and optimized protocol for positron emmsion tomography, the following are recommended: reconstruction matrix is 400 x 400. At BMI <, 30 both PET/CT and PET/MRI can be used at BMI >, 30 is recommended PET/CT. Optimal time between injection and start scan is between 120 and 200 minutes, and optimal time between injection and PET-scan. Method: 30 patients were injected with one dose of 18F-PSMA-1007 before PET/CT and PET/MR were performed on the same day. SUVmax from selected lesions was measured for assessment of reconstruction matrix and for optimizing time between injection and PET-scan. A subjective visual assessment of the lesions of both matrixes was also carried out. Standard deviation and mean counts was measured in the liver before calculating coeffisient of varianse (COV) to assess which modality is best for different BMI. For optimizing time between injection and PET-scan, PET

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