Authors: Williams, Tim D, Davies, Ian M, Wu, Huifeng, Diab, Amer, Webster, Lynda, Viant, Mark R, Chipman, James Kevin, Leaver, Michael, George, Stephen, Moffat, Colin F, Robinson, Craig D
Contributors: University of Birmingham, Scottish Government - Enterprise, Environment & Digital - Marine Scotland, Institute of Aquaculture, orcid:0000-0002-3155-0844
Subject Terms: Sediments, Flounder, Toxicogenomics, Microarray, Metabolomics, Genotoxicity
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Relation: Williams TD, Davies IM, Wu H, Diab A, Webster L, Viant MR, Chipman JK, Leaver M, George S, Moffat CF & Robinson CD (2014) Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments. Chemosphere, 108, pp. 152-158. https://doi.org/10.1016/j.chemosphere.2014.01.028; http://hdl.handle.net/1893/20197; WOS:000337881600020; 2-s2.0-84901588725; 630417; http://dspace.stir.ac.uk/bitstream/1893/20197/1/Chemosphere%202014.pdf
Authors: Williams, Tim D, Turan, Nil, Diab, Amer, Wu, Huifeng, Mackenzie, Carolynn, Bartie, Katie L, Hrydziuszko, Olga, Lyons, Brett P, Stentiford, Grant D, Herbert, John M, Abraham, Joseph K, Katsiadaki, Ioanna, Leaver, Michael, Taggart, John, George, Stephen, Viant, Mark R, Chipman, James Kevin, Falciani, Francesco
Contributors: University of Birmingham, Institute of Aquaculture, University of Stirling, CEFAS - Centre for Environment, Fisheries and Aquaculture Science, Case Western Reserve University, orcid:0000-0003-3037-5295, orcid:0000-0002-3155-0844, orcid:0000-0002-3843-9663
Subject Terms: pollution, environment, Populations dynamics, Water Pollution, Computational Biology, Systems biology
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Relation: Williams TD, Turan N, Diab A, Wu H, Mackenzie C, Bartie KL, Hrydziuszko O, Lyons BP, Stentiford GD, Herbert JM, Abraham JK, Katsiadaki I, Leaver M, Taggart J, George S, Viant MR, Chipman JK & Falciani F (2011) Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach. PLoS Computational Biology, 7 (Issue 8, Article e1002126). http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002126#; https://doi.org/10.1371/journal.pcbi.1002126; http://hdl.handle.net/1893/3737; http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002126#; WOS:000294299700010; 2-s2.0-80052324168; 792059; http://dspace.stir.ac.uk/bitstream/1893/3737/1/WilliamsPLOSCompBiol2011storre.pdf
Authors: Minghetti, Matteo, Leaver, Michael, Taggart, John, Casadei, Elisa, Auslander, Meirav, Tom, Moshe, George, Stephen
Contributors: Institute of Aquaculture, University of Stirling, Israel Oceanographic and Limnological Research, orcid:0000-0002-3155-0844, orcid:0000-0002-3843-9663
Subject Terms: Copper, Metals, ATP7A, MT, Microarray, qRT-PCR, Fish, Sparus aurata, Fishes Feeding and feeds, Aquaculture, Fishes Nutrition
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Relation: Minghetti M, Leaver M, Taggart J, Casadei E, Auslander M, Tom M & George S (2011) Copper induces Cu-ATPase ATP7A mRNA in a fish cell line, SAF1. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 154 (2), pp. 93-99. http://www.sciencedirect.com/science/article/pii/S153204561100055X; https://doi.org/10.1016/j.cbpc.2011.03.010; http://hdl.handle.net/1893/3731; http://www.sciencedirect.com/science/article/pii/S153204561100055X; WOS:000292179100004; 2-s2.0-79957741558; 792142; http://dspace.stir.ac.uk/bitstream/1893/3731/1/MinghettiCBPC2011storre.pdf
Authors: Leaver, Michael, Diab, Amer, Boukouvala, Evridiki, Williams, Tim D, Chipman, James Kevin, Moffat, Colin F, Robinson, Craig D, George, Stephen
Contributors: Institute of Aquaculture, National Agricultural Research Foundation, University of Birmingham, Scottish Government - Enterprise, Environment & Digital - Marine Scotland, orcid:0000-0002-3155-0844
Subject Terms: ecotoxicolgy, microarray, flounder, sediment, Diablo, cyp1A, Lipoproteins Fish, Fishes Feeding and feeds, Dietary supplements, Atlantic salmon
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Relation: Leaver M, Diab A, Boukouvala E, Williams TD, Chipman JK, Moffat CF, Robinson CD & George S (2010) Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure ‘biomarker’ signals and induction of inflammatory, innate immune and apoptotic pathways. Aquatic Toxicology, 96 (3), pp. 234-245. http://www.sciencedirect.com/science/journal/0166445X; https://doi.org/10.1016/j.aquatox.2009.10.025; http://hdl.handle.net/1893/2051; http://www.sciencedirect.com/science/journal/0166445X; WOS:000274950000007; 2-s2.0-75449092200; 837688; http://dspace.stir.ac.uk/bitstream/1893/2051/1/LeaverAqTox2009TextRevisedforSTORRE.pdf
Authors: Minghetti, Matteo, Leaver, Michael, George, Stephen
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
Subject Terms: copper, fish, homeostasis, Cu-ATPases, ATP7A, ATP7B, ATOX1
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Relation: Minghetti M, Leaver M & George S (2010) Multiple Cu-ATPase genes are differentially expressed and transcriptionally regulated by Cu exposure in sea bream, Sparus aurata. Aquatic Toxicology, 97 (1), pp. 23-33. http://www.sciencedirect.com/science/journal/0166445X; https://doi.org/10.1016/j.aquatox.2009.11.017; http://hdl.handle.net/1893/2487; http://www.sciencedirect.com/science/journal/0166445X; WOS:000276124600004; 2-s2.0-77549083085; 838392; http://dspace.stir.ac.uk/bitstream/1893/2487/1/Cu-ATPases%20paper-STORRE.pdf
Contributors: Institute of Aquaculture, University of Bologna, orcid:0000-0002-3155-0844
Subject Terms: copper, Sparus aurata, dietary copper, waterborne copper, Ctr1, gene expression, metallothionein, glutathione reductase, Fishes Feeding and feeds, Atlantic salmon, Dietary supplements, Lipoproteins Fish
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Relation: Minghetti M, Leaver M, Carpene E & George S (2008) Copper transporter 1, metallothionein and glutathione reductase genes are differentially expressed in tissues of sea bream (Sparus aurata) after exposure to dietary or waterborne copper. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 147 (4), pp. 450-459. http://www.sciencedirect.com/science/journal/15320456; https://doi.org/10.1016/j.cbpc.2008.01.014; http://hdl.handle.net/1893/2567; http://www.sciencedirect.com/science/journal/15320456; WOS:000255506400007; 2-s2.0-41449085129; 837576; http://dspace.stir.ac.uk/bitstream/1893/2567/1/Minghetti15323complete.pdf
Contributors: Institute of Aquaculture, University of Stirling, National Agricultural Research Foundation, orcid:0000-0002-3155-0844
Subject Terms: UDP-glucuronosyltransferase, detoxification, flounder, Pleuronectes, pollution, gene, Lipoproteins Fish, Fishes Feeding and feeds, Dietary supplements, Glucuronosyltransferase
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Relation: Leaver M, Wright J, Hodgson P, Boukouvala E & George S (2007) Piscine UDP-glucuronosyltransferase 1B. Aquatic Toxicology, 84 (3), pp. 356-365. http://www.sciencedirect.com/science/journal/0166445X; https://doi.org/10.1016/j.aquatox.2007.06.015; http://hdl.handle.net/1893/1588; http://www.sciencedirect.com/science/journal/0166445X; WOS:000249569400007; 2-s2.0-34547962315; 836343; http://dspace.stir.ac.uk/bitstream/1893/1588/1/LeaverAQTox2007finpost.pdf
Authors: Martinez-Lara, Esther, Leaver, Michael, George, Stephen
Contributors: University of Caen, Institute of Aquaculture, orcid:0000-0002-3155-0844
Subject Terms: plaice, glutathione-S-transferase, lipid oxidation
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Relation: Martinez-Lara E, Leaver M & George S (2002) Evidence from heterologous expression of glutathione S-transferases A and A1 of the plaice (Pleuronectes platessa) that their endogenous role is in detoxification of lipid peroxidation products. Marine Environmental Research, 54 (3-5), pp. 263-266. http://www.sciencedirect.com/science/article/pii/S0141113602001885; https://doi.org/10.1016/S0141-1136%2802%2900188-5; http://hdl.handle.net/1893/7615; http://www.sciencedirect.com/science/article/pii/S0141113602001885; WOS:000178360100012; 2-s2.0-0036753429; 791882; http://dspace.stir.ac.uk/bitstream/1893/7615/1/1-s2.0-S0141113602001885-main.pdf
Authors: George, Stephen, Leaver, Michael
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
Subject Terms: UDP-glucuronosyltransferase, glucuronidation, plaice, alleles, genetic polymorphism, pollutants
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Relation: George S & Leaver M (2002) Allelic variations in the plaice UGT1B1 gene. Marine Environmental Research, 54 (3-5), pp. 259-262. http://www.sciencedirect.com/science/article/pii/S0141113602001873; https://doi.org/10.1016/S0141-1136%2802%2900187-3; http://hdl.handle.net/1893/7625; http://www.sciencedirect.com/science/article/pii/S0141113602001873; WOS:000178360100011; 2-s2.0-0036753489; 890997; http://dspace.stir.ac.uk/bitstream/1893/7625/1/1-s2.0-S0141113602001873-main.pdf
Authors: Godard, Celine A J, Leaver, Michael, Said, Maya R, Dickerson, Richard L, George, Stephen, Stegeman, John J
Contributors: Woods Hole Oceanographic Institution, Institute of Aquaculture, Texas Tech University, orcid:0000-0002-3155-0844
Subject Terms: cytochrome P450, gene sequence, dolphin, cloning, scup
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Relation: Godard CAJ, Leaver M, Said MR, Dickerson RL, George S & Stegeman JJ (2000) Identification of cytochrome P4501B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Marine Environmental Research, 50 (1-5), pp. 7-10. http://www.sciencedirect.com/science/article/pii/S0141113600000520; https://doi.org/10.1016/S0141-1136%2800%2900052-0; http://hdl.handle.net/1893/7603; http://www.sciencedirect.com/science/article/pii/S0141113600000520; WOS:000165486700004; 2-s2.0-0033755978; 791862; http://dspace.stir.ac.uk/bitstream/1893/7603/1/1-s2.0-S0141113600000520-main.pdf
Authors: Leaver, Michael, George, Stephen
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
Subject Terms: carcinogens, CYP1A1, flatfish, pollution, polyaromatic hydrocarbon
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Relation: Leaver M & George S (2000) A cytochrome P4501B gene from a fish, Pleuronectes platessa. Gene, 256 (1-2), pp. 83-91. http://www.sciencedirect.com/science/article/pii/S0378111900003735; https://doi.org/10.1016/S0378-1119%2800%2900373-5; http://hdl.handle.net/1893/7627; http://www.sciencedirect.com/science/article/pii/S0378111900003735; WOS:000165170000010; 2-s2.0-0034601716; 791944; http://dspace.stir.ac.uk/bitstream/1893/7627/1/1-s2.0-S0378111900003735-main.pdf
Authors: George, Stephen, Leaver, Michael, Wright, Joy
Contributors: Institute of Aquaculture, University of Stirling, orcid:0000-0002-3155-0844
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Relation: George S, Leaver M & Wright J (1998) Structural studies of a UDP-glucuronosyltransferase gene from the plaice (Pleuronectes platessa). Marine Environmental Research, 46 (1-5), pp. 33-35. http://www.sciencedirect.com/science/article/pii/S0141113697000536; https://doi.org/10.1016/S0141-1136%2897%2900053-6; http://hdl.handle.net/1893/7620; http://www.sciencedirect.com/science/article/pii/S0141113697000536; WOS:000075806100009; 2-s2.0-0032124485; 791824; http://dspace.stir.ac.uk/bitstream/1893/7620/1/1-s2.0-S0141113697000536-main.pdf
Authors: Leaver, Michael, George, Stephen
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
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Relation: Leaver M & George S (1998) A piscine glutathione S-transferase which efficiently conjugates the end-products of lipid peroxidation. Marine Environmental Research, 46 (1-5), pp. 71-74. http://www.sciencedirect.com/science/article/pii/S0141113697000718; https://doi.org/10.1016/S0141-1136%2897%2900071-8; http://hdl.handle.net/1893/7631; http://www.sciencedirect.com/science/article/pii/S0141113697000718; WOS:000075806100017; 2-s2.0-0032122371; 791896; http://dspace.stir.ac.uk/bitstream/1893/7631/1/1-s2.0-S0141113697000718-main.pdf
Authors: Leaver, Michael, Wright, Joy, George, Stephen
Contributors: Institute of Aquaculture, University of Stirling, orcid:0000-0002-3155-0844
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Relation: Leaver M, Wright J & George S (1998) A peroxisomal proliferator-activated receptor gene from the marine flatfish, the plaice (Pleuronectes platessa). Marine Environmental Research, 46 (1-5), pp. 75-79. http://www.sciencedirect.com/science/article/pii/S0141113697000706; https://doi.org/10.1016/S0141-1136%2897%2900070-6; http://hdl.handle.net/1893/7630; http://www.sciencedirect.com/science/article/pii/S0141113697000706; WOS:000075806100018; 2-s2.0-0032124368; 791908; http://dspace.stir.ac.uk/bitstream/1893/7630/1/1-s2.0-S0141113697000706-main.pdf
Authors: Leaver, Michael, Wright, Joy, George, Stephen
Contributors: Institute of Aquaculture, University of Stirling, orcid:0000-0002-3155-0844
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Relation: Leaver M, Wright J & George S (1997) Structure and expression of a cluster of glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa). Biochemical Journal, 321 (Pt. 2), pp. 405-412. http://www.biochemj.org/bj/321/bj3210405.htm; http://hdl.handle.net/1893/7704; http://www.biochemj.org/bj/321/bj3210405.htm; WOS:A1997WE00400019; 2-s2.0-0031037288; 791702; http://dspace.stir.ac.uk/bitstream/1893/7704/1/9020873.pdf
Availability:
http://hdl.handle.net/1893/7704
http://www.biochemj.org/bj/321/bj3210405.htm
http://dspace.stir.ac.uk/bitstream/1893/7704/1/9020873.pdf
Authors: Leaver, Michael, George, Stephen
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
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Relation: Leaver M & George S (1996) Three repeated glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa). Marine Environmental Research, 42 (1-4), pp. 19-23. http://www.sciencedirect.com/science/article/pii/0141113695000801; https://doi.org/10.1016/0141-1136%2895%2900080-1; http://hdl.handle.net/1893/7705; http://www.sciencedirect.com/science/article/pii/0141113695000801; WOS:A1996UU36900005; 2-s2.0-0029979959; 791678; http://dspace.stir.ac.uk/bitstream/1893/7705/1/1-s2.0-0141113695000801-main.pdf
Contributors: University of Stirling, Institute of Aquaculture, Northern Ontario School of Medicine, McGill University, orcid:0000-0002-3155-0844
Subject Terms: troponin I, muscle protein, fish, molecular sequence data, evolution, vertebrate, (Clupea harengus)
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Relation: Hodgson P, Leaver M, George S, Maclean D & Hastings KEM (1996) Molecular cloning of troponin I expressed in fast white muscle of a teleost fish, the Atlantic herring (Clupea harengus L). Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1306 (2-3), pp. 142-146. http://www.sciencedirect.com/science/article/pii/0167478196000334; https://doi.org/10.1016/0167-4781%2896%2900033-4; http://hdl.handle.net/1893/7726; http://www.sciencedirect.com/science/article/pii/0167478196000334; WOS:A1996UM51500006; 2-s2.0-0029889939; 791728; http://dspace.stir.ac.uk/bitstream/1893/7726/1/1-s2.0-0167478196000334-main.pdf
Authors: Leaver, Michael, George, Stephen
Contributors: Institute of Aquaculture, orcid:0000-0002-3155-0844
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Relation: Leaver M & George S (1995) Structure of the plaice glutathione S-transferase A gene. Marine Environmental Research, 39 (1-4), pp. 33-37. http://www.sciencedirect.com/science/article/pii/014111369400051P; https://doi.org/10.1016/0141-1136%2894%2900051-P; http://hdl.handle.net/1893/7715; http://www.sciencedirect.com/science/article/pii/014111369400051P; WOS:A1995QR26100008; 2-s2.0-0028945985; 791690; http://dspace.stir.ac.uk/bitstream/1893/7715/1/1-s2.0-014111369400051P-main.pdf
Authors: Hitchman, N, Leaver, Michael, George, Stephen
Contributors: University of Stirling, Institute of Aquaculture, orcid:0000-0002-3155-0844
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Relation: Hitchman N, Leaver M & George S (1995) Alternatives to whole animal testing: Use of cDNA probes for studies of phase I and II enzyme induction in isolated plaice hepatocytes. Marine Environmental Research, 39 (1-4), pp. 289-292. http://www.sciencedirect.com/science/article/pii/014111369400039R; https://doi.org/10.1016/0141-1136%2894%2900039-R; http://hdl.handle.net/1893/7685; http://www.sciencedirect.com/science/article/pii/014111369400039R; WOS:A1995QR26100059; 2-s2.0-0028925942; 791810; http://dspace.stir.ac.uk/bitstream/1893/7685/1/1-s2.0-014111369400039R-main.pdf
Authors: Pirrit, Lindsay A, Healey, R, Assheton, H, Leaver, Michael, George, Stephen
Contributors: University of Stirling, Institute of Aquaculture, orcid:0000-0002-3155-0844
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Relation: Pirrit LA, Healey R, Assheton H, Leaver M & George S (1995) Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver. Marine Environmental Research, 39 (1-4), pp. 15-19. http://www.sciencedirect.com/science/article/pii/014111369400065W; https://doi.org/10.1016/0141-1136%2894%2900065-W; http://hdl.handle.net/1893/7682; http://www.sciencedirect.com/science/article/pii/014111369400065W; WOS:A1995QR26100005; 2-s2.0-0028902970; 791792; http://dspace.stir.ac.uk/bitstream/1893/7682/1/1-s2.0-014111369400065W-main.pdf