Authors: Bildsoe, Heidi, Fan, Xiaochen, Wilkie, Emilie E., Ashoti, Ator, Jones, Vanessa J., Power, Melinda, Qin, Jing, Wang, Junwen, Tam, Patrick P L, Loebel, David A F
Superior Title: Bildsoe , H , Fan , X , Wilkie , E E , Ashoti , A , Jones , V J , Power , M , Qin , J , Wang , J , Tam , P P L & Loebel , D A F 2016 , ' Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance ' , Developmental Biology , vol. 418 , no. 1 , pp. 189-203 . https://doi.org/10.1016/j.ydbio.2016.08.016
Subject Terms: bHLH factor, Cranial mesoderm, Craniofacial, Extracellular matrix-cell interaction, Mesenchyme, Twist1, PROMOTES TUMOR-METASTASIS, DOMAIN RECEPTOR 2, CRANIOFACIAL MUSCLES, BETA-IG-H3 INTERACTS, BREAST-CANCER, NEURAL-TUBE, TGF-BETA, PROTEIN, DIFFERENTIATION, MORPHOGENESIS
File Description: application/pdf
Availability:
https://doi.org/10.1016/j.ydbio.2016.08.016
https://hdl.handle.net/11370/1bca08be-7ccc-4e13-b847-8fe7d18821c3
https://research.rug.nl/en/publications/1bca08be-7ccc-4e13-b847-8fe7d18821c3
https://pure.rug.nl/ws/files/61923099/Transcriptional_targets_of_TWIST1_in_the_cranial_mesoderm_regulate_cell_matrix_interactions_and_mesenchyme_maintenance.pdf
Authors: Sambathkumar, Rangarajan, Kalo, Eric, Van Rossom, Rob, Faas, Marijke M., de Vos, Paul, Verfaillie, Catherine M.
Superior Title: Sambathkumar , R , Kalo , E , Van Rossom , R , Faas , M M , de Vos , P & Verfaillie , C M 2016 , ' Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts ' , Stem cells international , vol. 2016 , 7654321 . https://doi.org/10.1155/2016/7654321
Subject Terms: Reprogramming can occur by the introduction of key transcription factors (TFs) as well as by epigenetic changes. We demonstrated, that histone deacetylase inhibitor (HDACi) Trichostatin A (TSA) combined with a chromatin remodeling medium (CRM), induced expression of a number of definitive endoderm and early and late pancreatic marker genes. When CRM was omitted, endoderm/pancreatic marker genes were not induced. Furthermore, treatment with DNA methyltransferase inhibitor (DNMTi), 5-azacytidine (5AZA) CRM did not affect gene expression changes, and when 5AZA was combined with TSA, no further increase, in gene expression of endoderm, pancreatic endoderm, and endocrine markers was seen over levels induced with TSA alone, Interestingly, TSA-CRM did not affect expression of pluripotency and hepatocyte genes but induced some mesoderm transcripts, Upon removal of TSA-CRM, the endoderm/pancreatic gene expression profile returned to baseline. Our findings underscore the, role epigenetic modification in transdifferentiation of one somatic cell into another. However, full reprogramming of fibroblasts to beta-cells will require combination of this approach with TF overexpression and/or culture of the partially reprogrammed cells under beta-cell specific conditions, INSULIN-SECRETING CELLS, PLURIPOTENT STEM-CELLS, BETA-CELLS, IN-VITRO, SMALL MOLECULES, DIFFERENTIATION, TRICHOSTATIN, CONVERSION, CHROMATIN, VIVO
File Description: application/pdf
Authors: Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A, Rodier, Francis, Toussaint, Wendy, Mitchell, James R, Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E T, Hoeijmakers, Jan H J, de Bruin, Alain, Hara, Eiji, Campisi, Judith
Superior Title: Demaria , M , Ohtani , N , Youssef , S A , Rodier , F , Toussaint , W , Mitchell , J R , Laberge , R-M , Vijg , J , Van Steeg , H , Dollé , M E T , Hoeijmakers , J H J , de Bruin , A , Hara , E & Campisi , J 2014 , ' An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA ' , Developmental Cell , vol. 31 , no. 6 , pp. 722-733 . https://doi.org/10.1016/j.devcel.2014.11.012
Subject Terms: Animals, Apoptosis, Cell Aging, Cell Differentiation, Endothelial Cells, Female, Fibroblasts, Luminescence, Male, Mesoderm, Mice, Transgenic, Myofibroblasts, Platelet-Derived Growth Factor, Transgenes, Wound Healing
File Description: application/pdf
Availability:
https://doi.org/10.1016/j.devcel.2014.11.012
https://hdl.handle.net/11370/8b1f88e3-01ec-46e8-b125-8cec922cedc0
https://research.rug.nl/en/publications/8b1f88e3-01ec-46e8-b125-8cec922cedc0
https://pure.rug.nl/ws/files/112659667/An_essential_role_for_senescent_cells_in_optimal_wound_healing.pdf
Authors: Chang, CB, Eggen, BJL, Weinstein, DC, Brivanlou, AH, Chang, Chenbei, Weinstein, Daniel C., Brivanlou, Ali H.
Superior Title: Chang , CB , Eggen , BJL , Weinstein , DC , Brivanlou , AH , Chang , C , Weinstein , D C & Brivanlou , A H 2003 , ' Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms ' , Developmental Biology , vol. 255 , no. 1 , pp. 1-11 . https://doi.org/10.1016/S0012-1606(02)00075-1
Subject Terms: FOLLISTATIN-RELATED GENE, EPIDERMAL GROWTH-FACTOR, MESODERM INDUCTION, VERTEBRATE DEVELOPMENT, SPEMANN ORGANIZER, NEURAL INDUCTION, TRANSMEMBRANE PROTEIN, XENOPUS FOLLISTATIN, EXPRESSION CLONING, DIRECT BINDING
File Description: application/pdf
Authors: Postma, A. V., Alders, M., Sylva, M., Bilardo, C. M., Pajkrt, E., van Rijn, R. R., Schulte-Merker, S., Bulk, S., Stefanovic, S., Ilgun, A., Barnett, P., Mannens, M. M. A. M., Moorman, A. F. M., Oostra, R. J., van Maarle, M. C.
Superior Title: Postma , A V , Alders , M , Sylva , M , Bilardo , C M , Pajkrt , E , van Rijn , R R , Schulte-Merker , S , Bulk , S , Stefanovic , S , Ilgun , A , Barnett , P , Mannens , M M A M , Moorman , A F M , Oostra , R J & van Maarle , M C 2014 , ' Mutations in the T (brachyury) gene cause a novel syndrome consisting of sacral agenesis, abnormal ossification of the vertebral bodies and a persistent notochordal canal ....
Subject Terms: Clinical Genetics, Developmental, Genome-Wide, Linkage, TRANSCRIPTION FACTOR, MESODERM FORMATION, SHORT-TAIL, MOUSE, PROTEIN, CELLS, EXPRESSION, DEFECTS, HOMOLOG, TARGET
Availability:
https://doi.org/10.1136/jmedgenet-2013-102001
http://hdl.handle.net/11370/485601fa-27b5-45ca-98f8-a7b708c630dc
https://research.rug.nl/en/publications/mutations-in-the-t-brachyury-gene-cause-a-novel-syndrome-consisting-of-sacral-agenesis-abnormal-ossification-of-the-vertebral-bodies-and-a-persistent-notochordal-canal(485601fa-27b5-45ca-98f8-a7b708c630dc).html
Authors: Loureiro, Jesús, Schilte, Margot, Aguilera, Abelardo, Albar-Vizcaíno, Patricia, Ramírez-Huesca, Marta, Pérez-Lozano, M Luisa, González-Mateo, Guadalupe, Aroeira, Luiz S, Selgas, Rafael, Mendoza, Lorea, Ortiz, Alberto, Ruíz-Ortega, Marta, van den Born, Jacob, Beelen, Robert H J, López-Cabrera, Manuel
Superior Title: Loureiro , J , Schilte , M , Aguilera , A , Albar-Vizcaíno , P , Ramírez-Huesca , M , Pérez-Lozano , M L , González-Mateo , G , Aroeira , L S , Selgas , R , Mendoza , L , Ortiz , A , Ruíz-Ortega , M , van den Born , J , Beelen , R H J & López-Cabrera , M 2010 , ' BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure ' , Nephrology, Dialysis, Transplantation , vol. 25 , no. 4 , pp. 1098-1108 . ....
Subject Terms: Actins/metabolism, Animals, Blotting, Western, Bone Morphogenetic Protein 7/physiology, Cadherins/metabolism, Cell Differentiation, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Epithelium/metabolism, Fibrosis, Humans, Immunoenzyme Techniques, Male, Mesoderm/metabolism, Peritoneal Dialysis, Peritoneum/metabolism, Rats, Wistar, Smad Proteins/metabolism, Transforming Growth Factor beta1/antagonists & inhibitors
Availability:
https://doi.org/10.1093/ndt/gfp618
http://hdl.handle.net/11370/8f1f12bd-f7a0-4201-a685-be470b37190c
https://research.rug.nl/en/publications/bmp7-blocks-mesenchymal-conversion-of-mesothelial-cells-and-prevents-peritoneal-damage-induced-by-dialysis-fluid-exposure(8f1f12bd-f7a0-4201-a685-be470b37190c).html
Authors: Roel, Giulietta, Gent, Yoony Y. J., Peterson-Maduro, Josi, Verbeek, Fons J., Destree, Olivier
Superior Title: Roel , G , Gent , Y Y J , Peterson-Maduro , J , Verbeek , F J & Destree , O 2009 , ' Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis ' , International journal of developmental biology , vol. 53 , no. 1 , pp. 81-89 . https://doi.org/10.1387/ijdb.072395gr ; ISSN:0214-6282
Subject Terms: lef1, Xenopus, tropicalis, knockdown, wnt, NEURAL CREST, DIFFERENTIAL EXPRESSION, SIGNALING PATHWAYS, PARAXIAL MESODERM, TRANSCRIPTION, EMBRYOS, LAEVIS, INDUCTION, MIGRATION, RECEPTOR
Availability:
https://doi.org/10.1387/ijdb.072395gr
http://hdl.handle.net/11370/1875c81d-841c-483a-ac68-89662f279a03
https://research.rug.nl/en/publications/lef1-plays-a-role-in-patterning-the-mesoderm-and-ectoderm-in-xenopus-tropicalis(1875c81d-841c-483a-ac68-89662f279a03).html
Authors: van den Born, Jacob, Salmivirta, Katriina, Henttinen, Tiina, Ostman, Nina, Ishimaru, Takeshi, Miyaura, Shuichi, Yoshida, Keiichi, Salmivirta, Markku
Superior Title: van den Born , J , Salmivirta , K , Henttinen , T , Ostman , N , Ishimaru , T , Miyaura , S , Yoshida , K & Salmivirta , M 2005 , ' Novel heparan sulfate structures revealed by monoclonal antibodies ' , The Journal of Biological Chemistry , vol. 280 , no. 21 , pp. 20516-20523 . https://doi.org/10.1074/jbc.M502065200 ; ISSN:0021-9258
Subject Terms: Acetylation, Animals, Antibodies, Monoclonal, Antibody Specificity, Basement Membrane/chemistry, Cervix Uteri/chemistry, Embryo, Mammalian, Epithelium/chemistry, Epitopes/analysis, Female, Glucuronic Acid/chemistry, Heparitin Sulfate/analysis, Humans, Immunohistochemistry, Mesoderm/chemistry, Mouth, Polysaccharides/chemistry, Rats, Sulfates/chemistry, Tissue Distribution, Tooth
Availability:
https://doi.org/10.1074/jbc.M502065200
http://hdl.handle.net/11370/3c578c5b-ff92-42d0-82db-5e87d7835fc6
https://research.rug.nl/en/publications/novel-heparan-sulfate-structures-revealed-by-monoclonal-antibodies(3c578c5b-ff92-42d0-82db-5e87d7835fc6).html
Authors: Erickson, RP, Dagenais, SL, Caulder, MS, Downs, CA, Herman, G, Jones, Marilyn C, Kerstjens-Frederikse, Wilhelmina, Lidral, AC, McDonald, M, Nelson, CC, Witte, M, Glover, TW
Superior Title: Erickson , RP , Dagenais , SL , Caulder , MS , Downs , CA , Herman , G , Jones , M C , Kerstjens-Frederikse , W , Lidral , AC , McDonald , M , Nelson , CC , Witte , M & Glover , TW 2001 , ' Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations ' , JOURNAL OF MEDICAL GENETICS , vol. 38 , no. 11 , pp. 761-766 . < http://www.ncbi.nlm.nih.gov/pubmed/11694548 > ; ISSN:0022-2593
Subject Terms: lymphoedema, distichiasis, forkhead gene, clinical heterogeneity, TRANSCRIPTION FACTOR, VASCULAR DEVELOPMENT, LYMPHEDEMA, MFH-1, EXPRESSION, MESODERM, FAMILY
Availability:
http://hdl.handle.net/11370/3a885e7e-6471-4c95-86c2-9d2e020bad85
https://research.rug.nl/en/publications/clinical-heterogeneity-in-lymphoedemadistichiasis-with-foxc2-truncating-mutations(3a885e7e-6471-4c95-86c2-9d2e020bad85).html
http://www.ncbi.nlm.nih.gov/pubmed/11694548
