Authors: Yassin, Kamal

Subject Terms: glucose homeostasis, type 2 diabetes, GK rats, L6 myotubes, hepatic glucose output, insulin sensitivity, sex differences

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Relation: I. Yassin K, Huyen V, Hoa NK, Östenson CG: Herbal extract of Gynostemma pentaphyllum decreases hepatic glucose output in type 2 diabetic Goto- Kakizaki rats. Int J Biomed Sci 2011; 7 (2): 131-136.; II. Oberg AI*, Yassin K*, Csikasz RI, Dehvari N, Shabalina IG, Hutchinson DS, Wilcke M, Ostenson CG, Bengtsson T: Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto- Kakizaki rats. PLoS ONE 2011;6:e22510. ::doi::10.1371/journal.pone.0022510 ::pmid::21818330 ::isi::000293175100029 (*Authors contributed equally to the work.); III. Yassin K, Li LS, Palmblad M, Efendic S, Berggren PO, Cerami A, Östenson CG: The non-hematopoietic erythropoietin analogue, ARA290, improves glucose tolerance and insulin release in GK rats, a model of type 2 diabetes. (Manuscript); IV. Gustavsson C, Yassin K, Wahlstrom E, Cheung L, Lindberg J, Brismar K, Ostenson CG, Norstedt G, Tollet-Egnell P: Sex-different hepatic glycogen content and glucose output in rats. BMC Biochemistry 2010;11:38. ::doi::10.1186/1471-2091-11-38 ::pmid::20863371 ::isi::00283060300001; http://hdl.handle.net/10616/40700

Availability: http://hdl.handle.net/10616/40700

Authors: Mayega, Roy William

Subject Terms: Type 2 diabetes, pre-diabetes, hypertension, abnormal glucose regulation, NCD prevention, low income setting, lifestyle, screening, primary care

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Relation: I. Mayega RW, Makumbi F, Rutebemberwa E, Peterson S, Östenson C-G, Tomson G, Guwatudde D. (2012). Modifiable Socio-Behavioural Factors Associated with Overweight and Hypertension among Persons Aged 35 to 60 Years in Eastern Uganda. PLoS ONE. 7(10): e47632. ::doi::10.1371/journal.pone.0047632 ::pmid::23077653 ::isi::000309995100147; II. Mayega RW, Guwatudde D, Makumbi F, Nakwagala FN, Peterson S, Tomson G, Östenson C-G. (2013). Diabetes and Pre-Diabetes among Persons Aged 35 to 60 Years in Eastern Uganda: Prevalence and Associated Factors. PLoS ONE. 8(8): e72554. ::doi::10.1371/journal.pone.0072554 ::pmid::23967317 ::isi::000323221500137; III. Mayega RW, Guwatudde D, Makumbi F, Nakwagala FN, Peterson S, Tomson G, Östenson C-G. (2014). Comparison of fasting plasma glucose and haemoglobin A1c point-of-care tests in screening for diabetes and abnormal glucose regulation in a rural low income setting. Diabetes Research and Clinical Practice. 104(1):112-20. ::doi::10.1016/j.diabres.2013.12.030 ::pmid::24456993; IV. Mayega RW, Etajak S, Rutebemberwa E, Tomson G, Kiguli J. 'Change means sacrificing a good life': Perceptions about severity of type 2 diabetes and preventive lifestyles among people afflicted or at high risk of type 2 diabetes in Iganga Uganda [Submitted]; http://hdl.handle.net/10616/41977

Availability: http://hdl.handle.net/10616/41977

Authors: Ehrström, Sophia

Subject Terms: Recurrent vulvovaginal candidiasis, localized provoked vulvodynia, vulvar vestibulitis syndrome, Hypothalamus Pituitary Adrenal-axis, salivary cortisol, chronic stress, morning awakening cortisol, oral glucose tolerance testing, glucose in vaginal secretions, plasma glucose, body mass index

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Relation: I. Ehrstrom SM, Kornfeld D, Thuresson J, Rylander E (2005). Signs of chronic stress in women with recurrent candida vulvovaginitis. Am J Obstet Gynecol. 193(4): 1376-81. ::doi::10.1016/j.ajog.2005.03.068 ::pmid::16202729 ::isi::000232408000014; II. Ehrstrom SM, Kornfeld D, Rylander E (2007). Perceived stress in women with recurrent vulvovaginal candidiasis. Journal of Psychosomatic Obstetrics and Gynecology. [Accepted] ::doi::10.1080/01674820601168176 ::pmid::17577760 ::isi::000206480600008; III. Ehrstrom S, Yu A, Rylander E (2006). Glucose in vaginal secretions before and after oral glucose tolerance testing in women with and without recurrent vulvovaginal candidiasis. Obstet Gynecol. 108(6): 1432-7. ::doi::10.1097/01.AOG.0000246800.38892.fc ::pmid::17138777 ::isi::000246769800014; IV. Ehrstrom SM, Yu A, Rylander E (2007). Influence of oral glucose tolerance testing on glucose in plasma and in vaginal secretion in women with and without recurrent vulvovaginal candidiasis with reference to oral contraceptive use. [Submitted]; V. Ehrstrom SM, Kornfeld D, Rylander E, Bohm-Starke N (2007). Chronic stress in women with localised provoked vulvodynia. [Submitted]; 20070427ehrs; http://hdl.handle.net/10616/38772

Availability: http://hdl.handle.net/10616/38772

Authors: Bartnik, Malgorzata Zofia

Subject Terms: Glucose metabolism, coronary artery disease, classification, prevalence, prognosis, risk oral glucose tolerance test, diabetes mellitus

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Relation: I. Bartnik M, Malmberg K, Hamsten A, Efendic S, Norhammar A, Silveira A, Tenerz A, Ohrvik J, Ryden L (2004). Abnormal glucose tolerance--a common risk factor in patients with acute myocardial infarction in comparison with population-based controls. J Intern Med. 256(4): 288-97. ::pmid::15367171; II. Bartnik M, Ryden L, Ferrari R, Malmberg K, Pyorala K, Simoons M, Standl E, Soler-Soler J, Ohrvik J; Euro Heart Survey Investigators (2004). The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart. Eur Heart J. 25(21): 1880-90. ::pmid::15522466; III. Bartnik M, Ohvik J, Ryden L, Malmberg K, Pyorala K, Standl E, Ferrari R, Simoons ML, Soler-Soler J,on behalf of the Euro Heart Survey Investigators (2005). Identifying abnormal glucose regulation in patients with coronary artery disease. A report from the Euro Heart Survey on diabetes and the heart. [Manuscript]; IV. Bartnik M, Malmberg K, Norhammar A, Tenerz A, Ohrvik J, Ryden L (2004). Newly detected abnormal glucose tolerance: an important predictor of long-term outcome after myocardial infarction. Eur Heart J. 25(22): 1990-7. ::pmid::15541834; 91-7140-401-5; 20050610bart; http://hdl.handle.net/10616/38884

Availability: http://hdl.handle.net/10616/38884

Authors: Sjöstrand, Fredrik

Subject Terms: Volume kinetics, osmosis, dehydration, rehydration, glucose solutions, glucose, hypovolemia, hypoglycemia, fluids, intravenous fluid therapy, fluid shifts, plasma volume, dilution, plasma dilution, intracellular hydration, central volume

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Relation: I. Sjostrand F, Edsberg L, Hahn RG (2001). Volume kinetics of glucose solutions given by intravenous infusion. Br J Anaesth. 87(6): 834-43. ::pmid::11878683; II. Sjostrand F, Hahn RG (2003). Validation of volume kinetic analysis of glucose 2.5% solution given by intravenous infusion. Br J Anaesth. 90(5): 600-7. ::pmid::12697587; III. Sjostrand F, Hahn RG (2004). Volume kinetics of glucose 2.5% solution during laparoscopic cholecystectomy. Br J Anaesth. 92(4): 485-92. Epub 2004 Feb 20. ::pmid::14977794; IV. Sjostarnd F, Nystrom T, Hahn R (2005). Planning intravenous rehydration with glucose 2.5% solution in type 2 diabetes. [Manuscript]; V. Sjostarnd F, Berndtsson D, Olsson J, Strandberg P, hahn R (2005). Intravenous infusions of glucose solutions may cause hypovolemia and hypoglycemia. [Manuscript]; 91-7140-235-7; 20050531sjos; http://hdl.handle.net/10616/39228

Availability: http://hdl.handle.net/10616/39228

Authors: Vu, Thi Thanh Huyen

Subject Terms: herbal medicine, type 2 diabetes, gynostemma pentaphyllum tea, insulin sensitivity, sulfonylureas, glucose tolerance

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Relation: I. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res 2010; 42: 353-357 ::doi::10.1055/s-0030-1248298 ::pmid::20213586 ::isi::000278063000010; II. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum tea therapy with sulfonylureas in randomly assigned type 2 diabetic patients. Submitted manuscript.; III. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma Pentaphyllum Extract Improves Insulin Sensitivity in Type 2 Diabetic Patients. Submitted manuscript.; IV. Kamal Y, Huyen VT, Hoa NK, Ostenson CG. Herbal extract of Gynostemma pentaphyllum decreases hepatic glucose output in type 2 diabetic GotoKakizaki rats. Int J Biomed Sci Vol.7 No.2 June 2011.; http://hdl.handle.net/10616/40703

Availability: http://hdl.handle.net/10616/40703

Authors: Xu, Weili

Subject Terms: Diabetes, borderline diabetes, dementia, Alzheimer¡¯s disease, vascular dementia, blood glucose, vascular comorbidities, prospective study, population-based twin study

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Relation: I. Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L (2004). Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology. 63(7): 1181-6. ::pmid::15477535; II. Xu W, Qiu C, Winblad B, Fratiglioni L (2007). The effect of borderline diabetes on the risk of dementia and Alzheimers disease. Diabetes. 56(1): 211-6. ::pmid::17192484; III. Xu WL, von Strauss E, Qiu CX, Winblad B, Fratiglioni L (2008). The relation of diabetes to Alzheimers disease: the role of glycemic control and vascular comorbidities. [Submitted]; IV. Xu WL, Qiu CX, Gatz M, Pedersen NL, Fratiglioni L (2008). Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. [Submitted]; 20080516xu; http://hdl.handle.net/10616/39082

Availability: http://hdl.handle.net/10616/39082

Authors: Anselmino, Matteo

Subject Terms: Coronary artery disease, diabetes, acute coronary syndromes, guidelines, prevention, evidence-based medications, revascularisation, insulin, oral glucose lowering drugs, risk stratification, artificial neural network

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Relation: I. Anselmino M, Bartnik M, Malmberg K, Ryden L; Euro Heart Survey Investigators (2007). "Management of coronary artery disease in patients with and without diabetes mellitus. Acute management reasonable but secondary prevention unacceptably poor: a report from the Euro Heart Survey on Diabetes and the Heart." Eur J Cardiovasc Prev Rehabil 14(1): 28-36 ::pmid::17301624; II. Anselmino M, Malmberg K, Ohrvik J, Ryden L; Euro Heart Survey Investigators (2008). "Evidence-based medication and revascularization: powerful tools in the management of patients with diabetes and coronary artery disease: a report from the Euro Heart Survey on diabetes and the heart." Eur J Cardiovasc Prev Rehabil 15(2): 216-23 ::pmid::18391651; III. Anselmino M, Ohrvik J, Malmberg K, Standl E, Ryden L; Euro Heart Survey Investigators (2008). "Glucose lowering treatment in patients with coronary artery disease is prognostically important not only in established but also in newly detected diabetes mellitus: a report from the Euro Heart Survey on Diabetes and the Heart." Eur Heart J 29(2): 177-84. Epub 2007 Dec 21 ::pmid::18156611; IV. Anselmino M, Malmberg K, Ryden L, Öhrvik J (2008). "A gluco-metabolic risk index predicting event free survival in patients with coronary artery disease." (Submitted); 20081219anse; http://hdl.handle.net/10616/37975

Availability: http://hdl.handle.net/10616/37975

Authors: Alkén, Jenny

Subject Terms: Ketone bodies, glucose production, SCOT deficiency, hypoglycemia

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Relation: I. Marcus C, Alkén J, Eriksson J, Blom L, Gustafsson J (2007). Insufficient ketone body use is the cause of ketotic hypoglycemia in one of a pair of homozygotic twins. J Clin Endocrinol Metab. 92(11): 4080-4. Epub 2007 Aug 7 ::pmid::17684053; II. Alkén J, Gustafsson J, Alm J, Marcus C (2008). Impaired ketone body metabolism: a cause of idiopathic ketotic hypoglycemia. [Submitted]; III. Alkén J, Alm J, Zemack H, Frithiof D, Gustafsson J, Wibom R, Marcus C (2008). Five novel mutations in the OXCT gene clinical characterization of a child and an adult. [Submitted]; IV. Alkén J, Petriczko E, Marcus C (2007). Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. Eur J Clin Nutr May. 16: Epub ahead of print ::pmid::17522614; 20080215alke; http://hdl.handle.net/10616/39184

Availability: http://hdl.handle.net/10616/39184

Authors: Calissendorff, Jan

Subject Terms: Leptin, ghrelin, octanoylated, PYY3-36, GLP-1, obestatin, alcohol, NPY, IGF-1, IGFBP-1, insulin, glucose, testosterone, cortisol, catecholamines

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Relation: I. Röjdmark S, Calissendorff J, Brismar K (2001). Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals. Clin Endocrinol. (Oxf) 55(5): 639-47. ::pmid::11894976; II. Calissendorff J, Brismar K, Röjdmark S (2004). Is decreased leptin secretion after alcohol ingestion catecholamine-mediated? Alcohol Alcohol 39(4): 281-6. ::pmid::15208157; III. Calissendorff J, Danielsson O, Brismar K, Röjdmark S (2005). Inhibitory effect of alcohol on ghrelin secretion in normal man. Eur J Endocrinol. 152(5): 743-7. ::pmid::15879360; IV. Calissendorff J, Danielsson O, Brismar K, Röjdmark S (2006). Alcohol ingestion does not affect serum levels of peptide YY but decreases both total and octanoylated ghrelin levels in healthy subjects. Metabolism. 55(12): 1625-9. ::pmid::17142135; V. Calissendorff J, Gustafsson T, Holst JJ, Brismar K, Röjdmark S (2008). Effect of alcohol on some appetite-regulating hormones in man. Does gastroprotection with sucralfate change the alcohol effect? [Submitted]; 20081219cali; http://hdl.handle.net/10616/37992

Availability: http://hdl.handle.net/10616/37992

Authors: Long, Yun Chau

Subject Terms: Skeletal muscle, metabolism, glucose, lipid, gene expression, AMP-activated protein kinase, calcineurin, exercise

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Relation: I. Long YC, Barnes BR, Mahlapuu M, Steiler TL, Martinsson S, Leng Y, Wallberg-Henriksson H, Andersson L, Zierath JR (2005). "Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle." Diabetologia 48(11): 2354-64. Epub 2005 Oct 20 ::pmid::16237515; II. Barnes BR, Long YC, Steiler TL, Leng Y, Galuska D, Wojtaszewski JF, Andersson L, Zierath JR (2005). "Changes in exercise-induced gene expression in 5-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice." Diabetes 54(12): 3484-9 ::pmid::16306365; III. Ryder JW, Long YC, Nilsson E, Mahlapuu M, Zierath JR (2005). "Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle." J Physiol 567(Pt 2): 379-86. Epub 2005 Jun 23 ::pmid::15975979; IV. Long YC, Glund S, Garcia-Roves PM, Zierath JR (2007). "Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression." J Biol Chem 282(3): 1607-14. Epub 2006 Nov 15 ::pmid::17107952; 20070413long; http://hdl.handle.net/10616/38419

Availability: http://hdl.handle.net/10616/38419

Authors: Glund, Stephan

Subject Terms: AMP-activated protein kinase, interleukin-6, exercise, glucose metabolism, lipid metabolism, adaptation to exercise

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Relation: I. Barnes BR, Glund S, Long YC, Hjälm G, Andersson L, Zierath JR (2005). "5-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics." FASEB J 19(7): 773-9 ::pmid::15857891; II. Treebak JT, Glund S, Deshmukh A, Klein DK, Long YC, Jensen TE, Jørgensen SB, Viollet B, Andersson L, Neumann D, Wallimann T, Richter EA, Chibalin AV, Zierath JR, Wojtaszewski JF (2006). "AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits." Diabetes 55(7): 2051-8 ::pmid::16804075; III. Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR (2007). "Role of AMPK in basal and AICAR-mediated IL-6 release from isolated mouse skeletal muscle." (Submitted); IV. Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A (2007). "Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle." Diabetes 56(6): 1630-7. Epub 2007 Mar 15 ::pmid::17363741; V. Al-Khalili L, Bouzakri K, Glund S, Lönnqvist F, Koistinen HA, Krook A (2006). "Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle." Mol Endocrinol 20(12): 3364-75. Epub 2006 Aug 31 ::pmid::16945991; 20071214glun; http://hdl.handle.net/10616/39021

Availability: http://hdl.handle.net/10616/39021

Authors: Sandström, Marie

Subject Terms: Skeletal muscle, glucose transport, contraction, ROS, AMPK, glycogen phosphorylase, glycogen synthase

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Relation: I. Katz A, Andersson DC, Yu J, Norman B, Sandstrom ME, Wieringa B, Westerblad H (2003). Contraction-mediated glycogenolysis in mouse skeletal muscle lacking creatine kinase: the role of phosphorylase b activation. J Physiol. 553(Pt 2): 523-31. ::doi::10.1113/jphysiol.2003.051078 ::pmid::12963789 ::isi::000187279700017; II. Sandstrom ME, Abbate F, Andersson DC, Zhang SJ, Westerblad H, Katz A (2004). Insulin-independent glycogen supercompensation in isolated mouse skeletal muscle: role of phosphorylase inactivation. Pflugers Arch. 448(5): 533-8. ::doi::10.1007/s00424-004-1280-7 ::pmid::15085341 ::isi::000223659600009; III. Sandstrom ME, Zhang SJ, Bruton J, Silva JP, Reid MB, Westerblad H, Katz A (2006). Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J Physiol. 575(Pt 1): 251-62. ::doi::10.1113/jphysiol.2006.110601 ::pmid::16777943 ::isi::000239623400022; IV. Zhang SJ, Andersson DC, Sandstrom ME, Westerblad H, Katz A (2006). Cross bridges account for only 20% of total ATP consumption during submaximal isometric contraction in mouse fast-twitch skeletal muscle. Am J Physiol Cell Physiol. 291(1): C147-54. ::doi::10.1152/ajpcell.00578.2005 ::pmid::16481370 ::isi::000238287500018; V. Sandström ME, Zhang S-J, Westerblad H, Katz A (2006). Mechanical load plays little role in contraction-mediated glucose transport in mouse skeletal muscle. [Submitted]; 91-7140-969-6; 20061124sand; http://hdl.handle.net/10616/37740

Availability: http://hdl.handle.net/10616/37740

Authors: Kuhl, Jeanette

Subject Terms: Acetyl CoA carboxylase, AMP-activated protein kinase, Glucose intolerance, Insulin secretion, Insulin sensitivity, Malonyl CoA, Malonyl CoA decarboxylase, Peroxisomal proliferator activated receptor ã co-activator 1 á, Type 2 diabetes heredity

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Relation: I. Kuhl J, Hilding A, Ostenson CG, Grill V, Efendic S, Bavenholm P (2005). Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity. Diabetologia. 48(1): 35-40. ::pmid::15619073; II. Bavenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S (2003). Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. J Clin Endocrinol Metab. 88(1): 82-7. ::pmid::12519834; III. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN (2006). Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 290(6): E1296-303. ::pmid::16434556; IV. Kuhl J, Ruderman N, Musi N, Goodyear L, Patti ME, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar T, Saha A, Efendic S, Bavenholm P (2006). Effects of Exercise Training on Phenotype Characteristics, Insulin Sensitivity and Malonyl CoA Regulation in Subjects with Type 2 Diabetes. [Manuscript]; 91-7140-839-8; 20061006kuhl; http://hdl.handle.net/10616/38077

Availability: http://hdl.handle.net/10616/38077

Authors: Vasilcanu, Daiana

Subject Terms: IGF-1R, chemoresistance, IR, glucose uptake, tyrosine kinase inhibitors

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Relation: I. Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M, Larsson O (2004). The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene. 23(47): 7854-62. ::doi::10.1038/sj.onc.1208065 ::pmid::15334055 ::isi::000224331600011; II. Ulfarsson E, Karstrom A, Yin S, Girnita A, Vasilcanu D, Thoren M, Kratz G, Hillman J, Axelson M, Larsson O, Girnita L (2005). Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res. 11(13): 4674-80. ::doi::10.1158/1078-0432.CCR-05-0129 ::pmid::16000560 ::isi::000230400300008; III. Vasilcanu D, Weng WH, Girnita A, Lui WO, Vasilcanu R, Axelson M, Larsson O, Larsson C, Girnita L (2006). The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection. [Accepted] ::doi::10.1038/sj.onc.1209339 ::pmid::16407828 ::isi::000237951000009; IV. Vasilcanu D, Girnita A, Vasilcanu R, Axelson M, Girnita L, Larsson O (2006). The IGF-1 receptor inhibitor PPP induces increased cellular uptake of glucose. Interactions between IGF-1R and insulin receptor? [Manuscript]; 91-7140-643-3; 20060203vasi; http://hdl.handle.net/10616/38121

Availability: http://hdl.handle.net/10616/38121

Authors: Svanfeldt, Monika

Subject Terms: Insulin sensitivity, insulin resistance, hyperinsulinaemic normoglycaemic clamps, wholebody glucose kinetics, whole-body protein kinetics, indirect calorimetry, surgery, carbohydrate loading, hypocaloric nutrition, bed rest and TPN

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Relation: I. Svanfeldt M, Thorell A, Brismar K, Nygren J, Ljungqvist O (2003). Effects of 3 days of "postoperative" low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects. Clin Nutr. 22(1): 31-8. ::doi::10.1054/clnu.2002.0589 ::pmid::12553947 ::isi::000180877200005; II. Svanfeldt M, Thorell A, Nygren J, Ljungqvist O (2006). Postoperative parenteral nutrition while proactively minimizing insulin resistance. Nutrition. [Accepted] ::doi::10.1016/j.nut.2005.06.013 ::pmid::16473497 ::isi::000237043500002; III. Svanfeldt M, Thorell A, Hausel J, Soop M, Nygren J, Ljungqvist O (2005). Effect of "preoperative" oral carbohydrate treatment on insulin action - a randomised cross-over unblinded study in healthy subjects. Clin Nutr. 24(5): 815-21. ::doi::10.1016/j.clnu.2005.05.002 ::pmid::15979768 ::isi::000232456300013; IV. Svanfeldt M, Thorell A, Hausel J, Soop M, Rooyackers O, Nygren J, Ljungqvist O (2006). Effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics. [Manuscript]; 91-7140-637-9; 20060217svan; http://hdl.handle.net/10616/39307

Availability: http://hdl.handle.net/10616/39307

Authors: Rajamand Ekberg, Neda

Subject Terms: Microdialysis, microdialysis flow rate, adipose tissue, glucose, lactate, pyruvate, glycerol, insulin, IGFBP- 1, OGTT

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Relation: I. Rajamand Ekberg N, Wisniewski N, Brismar K, Ungerstedt U (2005). Measurement of glucose and metabolites in subcutaneous adipose tissue during hyperglycemia with microdialysis at various perfusion flow rates. Clinica Chimera Acta. [Accepted] ::doi::10.1016/j.cccn.2005.03.033 ::pmid::15939412 ::isi::000231532800004; II. Wisniewski N, Rajamand N, Adamsson U, Lins PE, Reichert WM, Klitzman B, Ungerstedt U (2002). Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats. Am J Physiol Endocrinol Metab. 282(6): E1316-23. ::doi::10.1152/ajpendo.00259.2001 ::pmid::12006362 ::isi::000175532000016; III. Rajamand Ekberg N, Wisniewski N, Adamson U, Hedblad MA, Ungerstedt U, Brismar K (2005). Analyte flux through chronically implanted subcutaneous microdialysis catheters in patients with diabetes mellitus. [Submitted]; IV. Rajamand N, Ungerstedt U, Brismar K (2005). Subcutaneous microdialysis before and after an oral glucose tolerance test: A method to determine insulin resistance in the subcutaneous adipose tissue in diabetes mellitus. Diabetes, Obesity & Metabolism. [Accepted] ::doi::10.1111/j.1463-1326.2004.00424.x ::pmid::16050945 ::isi::000230886000008; V. Rajamand N, Gave L, Brismar K (2005). Comparison between oral glucose tolerance test and a standardized meal with regards to glucose metabolism in subcutaneous adipose tissue in healthy subject. [Manuscript]; 91-7140-334-5; 20050617raja; http://hdl.handle.net/10616/39444

Availability: http://hdl.handle.net/10616/39444

Authors: Steiler, Tatiana L

Subject Terms: Skeletal muscle, insulin resistance, T2DM, hyperglycemia, high fat diet, glucose transport, PI3K-, MAPK- and AMPK-signaling pathways, AMPKgamma3

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Relation: I. Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR (2003). "Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats." Endocrinology 144(12): 5259-67. Epub 2003 Aug 21 ::pmid::12960081; II. Leng Y, Steiler TL, Zierath JR (2004). "Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice. " Diabetes 53(6): 1436-44 ::pmid::15161746; III. Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR (2002). "Isoform-specific regulation of 5 AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. " Diabetes 51(9): 2703-8 ::pmid::12196462; IV. Barnes BR, Marklund S, Steiler TL, Walter M, Hjalm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L (2004). "The 5-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. " J Biol Chem 279(37): 38441-7. Epub 2004 Jul 06 ::pmid::15247217; 91-7140-201-2; 20050330stei; http://hdl.handle.net/10616/38675

Availability: http://hdl.handle.net/10616/38675

Authors: Karlsson, Håkan K R

Subject Terms: Skeletal muscle, insulin resistance, type 2 diabetes, glucose transport, insulin signaling, first-degree relatives, AS160, SelS, rosiglitazone treatment

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Relation: I. Karlsson HKR, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H (2005). Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 54(6): 1692-7. ::doi::10.2337/diabetes.54.6.1692 ::pmid::15919790 ::isi::000229499600010; II. Karlsson HKR, Hallsten K, Bjornholm M, Tsuchida H, Chibalin AV, Virtanen KA, Heinonen OJ, Lonnqvist F, Nuutila P, Zierath JR (2005). Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes. 54(5): 1459-67. ::doi::10.2337/diabetes.54.5.1459 ::pmid::15855334 ::isi::000228701000027; III. Karlsson HKR, Ahlsen M, Zierath JR, Wallberg-Henriksson H, Koistinen HA (2005). Insulin signaling to glucose transport in skeletal muscle from first-degree relatives of subjects with type 2 diabetes. [Submitted]; IV. Karlsson HKR, Tsuchida H, Lake S, Koistinen HA, Krook A (2004). Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects. Diabetes. 53(6): 1424-8. ::doi::10.2337/diabetes.53.6.1424 ::pmid::15161744 ::isi::000221690200004; 91-7140-469-4; 20050909karl; http://hdl.handle.net/10616/39723

Availability: http://hdl.handle.net/10616/39723

Authors: Norhammar, Anna

Subject Terms: Diabetes, glucose tolerance, hyperglycemia, prognosis, risk, mortality, prevalence, myocardial infarction

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Relation: I. Malmberg K, Norhammar A, Wedel H, Ryden L (1999). Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study. Circulation. 99(20): 2626-32. ::pmid::10338454; II. Norhammar AM, Ryden L, Malmberg K (1999). Admission plasma glucose. Independent risk factor for long-term prognosis after myocardial infarction even in nondiabetic patients. Diabetes Care. 22(11): 1827-31. ::pmid::10546015; III. Norhammar A, Tenerz A, Nilsson G, Hamsten A, Efendic S, Ryden L, Malmberg K (2002). Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet. 359(9324): 2140-4. ::pmid::12090978; IV. Norhammar A, Malmberg K, Ryden L, Tornvall P, Stenestrand U, Wallentin L (2003). Under utilisation of evidence-based treatment partial explanation for the unfavourable prognosis in diabetic patients with acute myocardial infarction. Eur Heart J. 24(9): 838-44. ::pmid::12727151; V. Norhammar A, Malmberg K, Diderholm E, Lagerqvist B, Lindahl B, Rydén L, Wallentin L (2003). Diabetes mellitus the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization. [Manuscript]; 91-7349-561-1; 20030613norh; http://hdl.handle.net/10616/38788

Availability: http://hdl.handle.net/10616/38788