Authors: Hamis, Sara J., Kapelyukh, Yury, McLaren, Aileen, Henderson, Colin J., Wolf, C. Roland, Chaplain, Mark A. J.
Superior Title: Hamis , S J , Kapelyukh , Y , McLaren , A , Henderson , C J , Wolf , C R & Chaplain , M A J 2021 , ' Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling ' , British Journal of Cancer , vol. 125 , pp. 1552-1560 . https://doi.org/10.1038/s41416-021-01565-w
Subject Terms: Computational science, Melanoma, Numerical simulations, /dk/atira/pure/subjectarea/asjc/2700/2730, name=Oncology, /dk/atira/pure/subjectarea/asjc/1300/1306, name=Cancer Research
File Description: application/pdf
Superior Title: Macfarlane , F R , Chaplain , M A J & Eftimie , R 2020 , ' Quantitative Predictive Modelling Approaches to Understanding Rheumatoid Arthritis : A Brief Review ' , Cells , vol. 9 , no. 1 , 74 . https://doi.org/10.3390/cells9010074
Subject Terms: rheumatoid arthritis, mathematical models, deterministic models, ODEs, PDEs, probabilistic models, /dk/atira/pure/subjectarea/asjc/2700/2700, name=General Medicine
File Description: application/pdf
Authors: Kim, Yangjin, Kang, Hyunji, Powathil, Gibin, Kim, Hyeongi, Trucu, Dumitru, Lee, Wanho, Lawler, Sean, Chaplain, Mark
Superior Title: Kim , Y , Kang , H , Powathil , G , Kim , H , Trucu , D , Lee , W , Lawler , S & Chaplain , M 2018 , ' Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma ' , PLoS ONE , vol. 13 , no. 10 , e0204865 , pp. 1-40 . https://doi.org/10.1371/journal.pone.0204865
Subject Terms: /dk/atira/pure/subjectarea/asjc/1300/1300, name=General Biochemistry,Genetics and Molecular Biology, /dk/atira/pure/subjectarea/asjc/1100/1100, name=General Agricultural and Biological Sciences
File Description: application/pdf
Authors: Domschke, Pia, Trucu, Dumitru, Gerisch, Alf, Chaplain, Mark A. J.
Superior Title: Domschke , P , Trucu , D , Gerisch , A & Chaplain , M A J 2017 , ' Structured models of cell migration incorporating molecular binding processes ' , Journal of Mathematical Biology , vol. 75 , no. 6-7 , pp. 1517-1561 . https://doi.org/10.1007/s00285-017-1120-y
Subject Terms: Strucutred population model, Spatio-temporal model, Cell-surface receptors, Cancer invasion
File Description: application/pdf
Authors: Bitsouni, Vasiliki, Chaplain, Mark, Eftimie, Raluca
Superior Title: Bitsouni , V , Chaplain , M & Eftimie , R 2017 , ' Mathematical Modelling of Cancer Invasion : The Multiple Roles of TGF-β Pathway on Tumour Proliferation and Cell Adhesion ' Mathematical Models and Methods in Applied Sciences , vol 27 , no. 10 , pp. 1929-1962 . DOI:10.1142/S021820251750035X
Subject Terms: Non-local model of cancer progression, Existence, Boundedness of solution, Cell heterogeneity, TGF-β, Cell-cell and cell-matrix adhesion
File Description: application/pdf
Availability:
https://doi.org/10.1142/S021820251750035X
http://discovery.dundee.ac.uk/portal/en/research/mathematical-modelling-of-cancer-invasion(111e3936-4faf-4480-b829-f8ba923e20d7).html
http://hdl.handle.net/10588/111e3936-4faf-4480-b829-f8ba923e20d7
http://discovery.dundee.ac.uk/ws/files/17454165/s021820251750035x.pdf
Authors: Chaplain, Mark, Ptashnyk, Mariya, Sturrock, Marc
Superior Title: Chaplain , M , Ptashnyk , M & Sturrock , M 2015 , ' Hopf bifurcation in a gene regulatory network model : Molecular movement causes oscillations ' Mathematical Models and Methods in Applied Sciences , vol 25 , no. 6 , pp. 1179-1215 . DOI:10.1142/S021820251550030X
Subject Terms: Gene regulatory network, Transcription factor, Negative feedback loop, Oscillations, Hopf bifurcation, Center manifold and normal form, Weakly nonlinear analysis
File Description: application/pdf
Availability:
https://doi.org/10.1142/S021820251550030X
http://discovery.dundee.ac.uk/portal/en/research/hopf-bifurcation-in-a-gene-regulatory-network-model(1b913f7f-755f-4eb1-9483-b6177f3afe1c).html
http://hdl.handle.net/10588/1b913f7f-755f-4eb1-9483-b6177f3afe1c
http://discovery.dundee.ac.uk/ws/files/8539003/s021820251550030x.pdf
Superior Title: Schluter , D K , Ramis-Conde , I & Chaplain , M A J 2015 , ' Multi-scale modelling of the dynamics of cell colonies : insights into cell-adhesion forces and cancer invasion from in silico simulations ' Journal of the Royal Society Interface , vol 12 , no. 103 , 20141080 , pp. 1-13 . DOI:10.1098/rsif.2014.1080
Subject Terms: Individual-based modelling, Cell population modelling, Cell-adhesion forces, E-cadherin
File Description: application/pdf
Availability:
https://doi.org/10.1098/rsif.2014.1080
http://discovery.dundee.ac.uk/portal/en/research/multiscale-modelling-of-the-dynamics-of-cell-colonies(8e4bfe80-ed3a-44a6-9b63-55807bba7122).html
http://hdl.handle.net/10588/8e4bfe80-ed3a-44a6-9b63-55807bba7122
http://discovery.dundee.ac.uk/ws/files/11515315/20141080.full.pdf
http://rsif.royalsocietypublishing.org/
Superior Title: Schlueter , D K , Ramis-Conde , I & Chaplain , M A J 2012 , ' Computational Modeling of Single-Cell Migration: The Leading Role of Extracellular Matrix Fibers ' , Biophysical Journal , vol. 103 , no. 6 , pp. 1141-1151 . https://doi.org/10.1016/j.bpj.2012.07.048
Subject Terms: ORIENTATION, FIBROBLASTS, ATOMIC-FORCE MICROSCOPY, INVASION, EPITHELIAL-MESENCHYMAL TRANSITION, MOVEMENT, QUANTITATIVE-ANALYSIS, SURFACES, DYNAMICS, MECHANISMS
File Description: application/pdf
Superior Title: Macnamara , C K , Mitchell , E I & Chaplain , M A J 2019 , ' Spatial-Stochastic modelling of synthetic gene regulatory networks ' , Journal of Theoretical Biology , vol. 468 , pp. 27-44 . https://doi.org/10.1016/j.jtbi.2019.02.003
Subject Terms: Activator-repressor systems, Repressilators, Spatial-stochastic modelling, Synthetic gene regulatory networks, /dk/atira/pure/subjectarea/asjc/2600/2613, name=Statistics and Probability, /dk/atira/pure/subjectarea/asjc/2600/2611, name=Modelling and Simulation, /dk/atira/pure/subjectarea/asjc/1300/1300, name=General Biochemistry,Genetics and Molecular Biology, /dk/atira/pure/subjectarea/asjc/2400/2400, name=General Immunology and Microbiology, /dk/atira/pure/subjectarea/asjc/1100/1100, name=General Agricultural and Biological Sciences, /dk/atira/pure/subjectarea/asjc/2600/2604, name=Applied Mathematics
Authors: Trucu, Dumitru, Domschke, Pia, Gerisch, Alf, Chaplain, Mark
Contributors: Preziosi, Luigi, Ciarletta, Pasquale, Hillen, Thomas, Chaplain, Mark, Pugliese, Andrea, Othmer, Hans, Truccu, Dumitru
Superior Title: Trucu , D , Domschke , P , Gerisch , A & Chaplain , M 2016 , Multiscale computational modelling and analysis of cancer invasion . in L Preziosi , P Ciarletta , T Hillen , M Chaplain , A Pugliese , H Othmer & D Truccu (eds) , Mathematical Models and Methods for Living Systems : Levico Terme, Italy 2014 . C.I.M.E. Foundation Subseries , vol. 2167 , Springer International Publishing , pp. 275-321 . https://doi.org/10.1007/978-3-319-42679-2_5
Subject Terms: Multiscale modelling, Cancer invasion, Computational simulations
Relation: https://discovery.dundee.ac.uk/en/publications/0b12fcdf-cd37-4740-9952-e026eeb718dc; urn:ISBN:9783319426785
Superior Title: Peng , L , Trucu , D , Lin , P , Thompson , A & Chaplain , M A J 2017 , ' A multiscale mathematical model of tumour invasive growth ' Bulletin of Mathematical Biology , vol 79 , no. 3 , pp. 389-429 . DOI:10.1007/s11538-016-0237-2
Authors: Szymańska, Zuzanna, Cytowski, Maciej, Mitchell, Elaine, Macnamara, Cicely K., Chaplain, Mark A. J.
Superior Title: Szymańska , Z , Cytowski , M , Mitchell , E , Macnamara , C K & Chaplain , M A J 2017 , ' Computational Modelling of Cancer Development and Growth : Modelling at Multiple Scales and Multiscale Modelling ' Bulletin of Mathematical Biology . DOI:10.1007/s11538-017-0292-3
Subject Terms: Multiscale cancer modelling, Gene regulatory network, Spatial stochastic model, Individual-based model, Computational simulations
Availability:
https://doi.org/10.1007/s11538-017-0292-3
http://discovery.dundee.ac.uk/portal/en/research/computational-modelling-of-cancer-development-and-growth(4d15fa8c-767f-4c49-b983-051f863fe50c).html
http://hdl.handle.net/10588/4d15fa8c-767f-4c49-b983-051f863fe50c
Authors: Burgess, Andrew E. F., Lorenzi, Tommaso, Schofield, Pietà G., Hubbard, Stephen F., Chaplain, Mark A. J.
Superior Title: Burgess , A E F , Lorenzi , T , Schofield , P G , Hubbard , S F & Chaplain , M A J 2017 , ' Examining the role of individual movement in promoting coexistence in a spatially explicit prisoner's dilemma ' , Journal of Theoretical Biology , vol. 419 , pp. 323-332 . https://doi.org/10.1016/j.jtbi.2017.02.028
Subject Terms: Spatial games, Random motion, Chemotaxis, Prisoner's dilemma, Spatial patterning
Superior Title: Powathil , G G , Munro , A J , Chaplain , M A J & Swat , M 2016 , ' Bystander effects and their implications for clinical radiation therapy : Insights from multiscale in silico experiments ' Journal of Theoretical Biology , vol 401 , pp. 1-14 . DOI:10.1016/j.jtbi.2016.04.010
Subject Terms: Cell-cycle, Multiscale mathematical model, Radiation therapy, Radiation-induced bystander effects, /dk/atira/pure/subjectarea/asjc/2600/2604, Applied Mathematics, /dk/atira/pure/subjectarea/asjc/2600/2613, Statistics and Probability, /dk/atira/pure/subjectarea/asjc/2600/2611, Modelling and Simulation, /dk/atira/pure/subjectarea/asjc/1100, Agricultural and Biological Sciences(all), /dk/atira/pure/subjectarea/asjc/1300, Biochemistry, Genetics and Molecular Biology(all), /dk/atira/pure/subjectarea/asjc/2400, Immunology and Microbiology(all), /dk/atira/pure/subjectarea/asjc/2700, Medicine(all)
Availability:
https://doi.org/10.1016/j.jtbi.2016.04.010
http://discovery.dundee.ac.uk/portal/en/research/bystander-effects-and-their-implications-for-clinical-radiation-therapy(3079b44e-9034-4664-aa2a-fb96b543956e).html
http://hdl.handle.net/10588/3079b44e-9034-4664-aa2a-fb96b543956e
http://www.scopus.com/inward/record.url?scp=84964438078&partnerID=8YFLogxK
Authors: Chaplain, Mark A. J., Powathil, Gibin G.
Superior Title: Chaplain , M A J & Powathil , G G 2015 , ' Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment ' Biophysical Reviews and Letters , vol 10 , no. 2 , pp. 97-114 . DOI:10.1142/S1793048015500058
Subject Terms: Cell-cycle pathway, Chemotherapy, Hypoxia, Multiscale modelling, /dk/atira/pure/subjectarea/asjc/1300/1304, Biophysics, /dk/atira/pure/subjectarea/asjc/1300/1312, Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1315, Structural Biology
Availability:
https://doi.org/10.1142/S1793048015500058
http://discovery.dundee.ac.uk/portal/en/research/multiscale-modelling-of-cancer-progression-and-treatment-control(e1520a2b-72e7-4e9c-8ac6-32059a4792fa).html
http://hdl.handle.net/10588/e1520a2b-72e7-4e9c-8ac6-32059a4792fa
http://www.scopus.com/inward/record.url?scp=84938751521&partnerID=8YFLogxK
Authors: Kim, Yangjin, Powathil, Gibin, Kang, Hyunji, Trucu, Dumitru, Kim, Hyeongi, Lawler, Sean, Chaplain, Mark
Superior Title: Kim , Y , Powathil , G , Kang , H , Trucu , D , Kim , H , Lawler , S & Chaplain , M 2015 , ' Strategies of eradicating glioma cells : A multi-scale mathematical model with miR-451-AMPK-mTOR control ' PLoS ONE , vol 10 , no. 1 , e0114370 . DOI:10.1371/journal.pone.0114370
File Description: application/pdf
Availability:
https://doi.org/10.1371/journal.pone.0114370
http://discovery.dundee.ac.uk/portal/en/research/strategies-of-eradicating-glioma-cells(f5f9d3d3-5a68-4d9e-b454-b2df3bb07e31).html
http://hdl.handle.net/10588/f5f9d3d3-5a68-4d9e-b454-b2df3bb07e31
http://discovery.dundee.ac.uk/ws/files/8466334/journal.pone.0114370.PDF
Authors: Powathil, Gibin G., Swat, Maciej, Chaplain, Mark A. J.
Superior Title: Powathil , G G , Swat , M & Chaplain , M A J 2015 , ' Systems oncology : towards patient-specific treatment regimes informed by multiscale mathematical modelling ' Seminars in Cancer Biology , vol 30 , pp. 13-20 . DOI:10.1016/j.semcancer.2014.02.003
Contributors: Jackson, Trachette L.
Superior Title: Anderson , A R A , Chaplain , M A J & McDougall , S 2012 , A hybrid discrete-continuum model of tumour induced angiogenesis . in T L Jackson (ed.) , Modeling tumor vasculature : molecular, cellular, and tissue level aspects and implications . Springer , New York , pp. 105-133 . https://doi.org/10.1007/978-1-4614-0052-3_5
Subject Terms: /dk/atira/pure/subjectarea/asjc/2700/2700, name=General Medicine
Relation: https://discovery.dundee.ac.uk/en/publications/9a5fd9b3-7ef7-4adb-b112-66932519cfb7; urn:ISBN:9781461400516; urn:ISBN:1461400511
Availability:
https://doi.org/10.1007/978-1-4614-0052-3_5
https://discovery.dundee.ac.uk/en/publications/9a5fd9b3-7ef7-4adb-b112-66932519cfb7
http://www.scopus.com/inward/record.url?scp=84928927940&partnerID=8YFLogxK
http://library.dundee.ac.uk/F/UAVCK8CYUUH3EAU6HA622K5H4E6KA7KBRUXJVBDTFKEM65V3BX-29187?func=find-e&adjacent=N&request=9781461400523&find_scan_code=FIND_WRD&x=0&y=0
Superior Title: Hughes , J , Gregor , P , Chaplain , M , Coleman , G & McIver , L 2009 , Research-teaching linkages : enhancing graduate attributes. Information and mathematical sciences . Quality Assurance Agency for Higher Education .
Availability:
http://discovery.dundee.ac.uk/portal/en/research/researchteaching-linkages(b7b58bfd-c74a-4a61-b726-a4665cb912df).html
http://hdl.handle.net/10588/b7b58bfd-c74a-4a61-b726-a4665cb912df
http://www.enhancementthemes.ac.uk/pages/docdetail/docs/publications/enhancing-graduate-attributes-information-and-mathematical-sciences
Authors: Wu, Min, Frieboes, Hermann B., Chaplain, Mark A. J., McDougall, Steven R., Cristini, Vittorio, Lowengrub, John S.
Superior Title: Wu , M , Frieboes , H B , Chaplain , M A J , McDougall , S R , Cristini , V & Lowengrub , J S 2014 , ' The effect of interstitial pressure on therapeutic agent transport : coupling with the tumor blood and lymphatic vascular systems ' , Journal of Theoretical Biology , vol. 355 , pp. 194-207 . https://doi.org/10.1016/j.jtbi.2014.04.012
Subject Terms: Chemotherapy, Cancer simulation, Tumor vasculature, Tumor lymphatics, Interstitial fluid pressure